Increased circulating erythrocyte-derived microparticles in patients with acute coronary syndromes
Increased circulating erythrocyte-derived microparticles in patients with acute coronary syndromes
复制标题
急性冠状动脉综合征患者循环红细胞衍生微粒增加
DOI：
10.2217/bmm-2021-0141
复制
发表时间：
2021
影响因子：
2.2
通讯作者：
Hui Zhu
中科院分区：
文献类型：
--
作者：
Hai-xia Liao;Lin-lin Meng;Xin Yu;Ming Song;Guo-kai Shang;Di Wang;Zhi-hao Wang;Wei Zhang;Ming Zhong;Hui Zhu
目的：探讨红细胞衍生微粒(ERMPs)对急性冠脉综合征(ACS)患者的预测价值。材料与方法：将305例受试者分为对照组和急性冠脉综合征组。流式细胞仪检测ERMPs的表达。根据冠状动脉造影结果计算Gensini评分。结果：与对照组相比，急性冠脉综合征组ERMPs浓度显著升高，且与急性冠脉综合征发病风险相关。ERMPs浓度和百分比与Gensini评分呈正相关。结论：ERMPs可能成为预测急性冠脉综合征危险性和冠状动脉病变严重程度的新的生物标志物。
Objective: This study is to explore the predictive value of erythrocyte-derived microparticles (ErMPs) in patients with acute coronary syndrome (ACS). Materials & methods: Total 305 subjects were enrolled and divided into the control group and ACS group. Flow cytometry was used to detect the ErMPs. The Gensini score was calculated based on the results of the coronary angiography. Results: Compared with that in the control group, the ErMPs concentration in the ACS group increased significantlyand the concentration of ErMPs was correlated with the ACS risk. The concentration of ErMPs and the percentage of ErMPs were positively correlated with the Gensini score. Conclusion: ErMPs may be a new biomarker for predicting the ACS risk and the coronary artery disease severity.