Inflammation, Infiltration, and Evasion-Tumor Promotion in the Aging Breast.
Inflammation, Infiltration, and Evasion-Tumor Promotion in the Aging Breast.
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炎症、浸润和逃逸--衰老乳腺中的肿瘤促进。
作者：
乳腺癌是影响全世界数百万妇女，特别是绝经后妇女的重大健康问题。虽然早期发现和治疗已经有所改善，但许多患者仍然发生转移性疾病。最近的研究集中在使用免疫系统来诊断和治疗乳腺癌。乳腺免疫微环境调节组织稳态和对肿瘤生长的抵抗。本文综述了免疫系统如何随年龄变化，这些变化如何影响乳腺癌的发展和进展，以及利用免疫系统的靶向治疗如何改善患者的预后。它强调了了解衰老，免疫系统和乳腺癌之间关系的重要性，以及基于免疫的疗法对抗这种毁灭性疾病的潜力。乳腺癌是妇女发病和死亡的重要原因，全世界每年报告的新病例超过200万例，其中大多数发生在绝经后妇女中。尽管在早期检测和治疗方面取得了进展，但大约三分之一被诊断患有乳腺癌的患者将发展为转移性疾病。乳腺癌的发病机制和进展受到多种生物学和社会风险因素的影响，包括年龄、种族、妊娠状况、饮食和基因组改变。乳腺癌研究的最新进展集中在利用患者的适应性和先天免疫系统的力量进行诊断和治疗。乳腺免疫微环境在调节组织稳态和抵抗肿瘤发生中起着关键作用。在这篇综述中，我们探讨了乳腺免疫微环境随年龄发生的动态变化，这些变化如何影响乳腺癌的发展和进展，以及如何利用免疫系统进行有针对性的治疗干预来改善患者的预后。我们的综述强调了了解衰老，免疫系统和乳腺癌之间复杂相互作用的重要性，并强调了基于免疫的疗法在对抗这种毁灭性疾病方面的潜力。
Breast cancer is a significant health problem affecting millions of women worldwide, particularly post-menopausal women. Although early detection and treatment have improved, many patients still develop metastatic disease. Recent research has focused on using the immune system to diagnose and treat breast cancer. The breast immune microenvironment regulates tissue homeostasis and resistance to tumor growth. This review examines how the immune system changes with age, how these changes affect breast cancer development and progression, and how targeted therapies that utilize the immune system can improve patient outcomes. It emphasizes the importance of understanding the relationship between aging, the immune system, and breast cancer, and the potential of immune-based therapies to combat this devastating disease. Breast cancer is a significant cause of morbidity and mortality in women, with over two million new cases reported worldwide each year, the majority of which occur in post-menopausal women. Despite advances in early detection and treatment, approximately one-third of patients diagnosed with breast cancer will develop metastatic disease. The pathogenesis and progression of breast cancer are influenced by a variety of biological and social risk factors, including age, ethnicity, pregnancy status, diet, and genomic alterations. Recent advancements in breast cancer research have focused on harnessing the power of the patient’s adaptive and innate immune systems for diagnostic and therapeutic purposes. The breast immune microenvironment plays a critical role in regulating tissue homeostasis and resistance to tumorigenesis. In this review, we explore the dynamic changes in the breast immune microenvironment that occur with age, how these changes impact breast cancer development and progression, and how targeted therapeutic interventions that leverage the immune system can be used to improve patient outcomes. Our review emphasizes the importance of understanding the complex interplay between aging, the immune system, and breast cancer, and highlights the potential of immune-based therapies in the fight against this devastating disease.
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影响因子：
11.5
作者：
Degnim, Amy C.;Hoskin, Tanya L.;Visscher, Daniel W.
通讯作者：
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影响因子：
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影响因子：
15.8
作者：
Ali HR;Chlon L;Pharoah PD;Markowetz F;Caldas C
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2.7
作者：
Brune K;Patrignani P
通讯作者：
Patrignani P
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168.9
作者：
Cortes, Javier;Cescon, David W.;Schmid, Peter
通讯作者：
Schmid, Peter