Multi-localized Proteins: The Peroxisome-Mitochondria Connection.
Multi-localized Proteins: The Peroxisome-Mitochondria Connection.
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DOI：
10.1007/978-981-13-2233-4_17
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发表时间：
2018-01-01
影响因子：
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通讯作者：
Schrader, Michael
中科院分区：
文献类型：
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作者：
Costello, Joseph L;Passmore, Josiah B;Schrader, Michael
过氧化物酶体和线粒体是动态的、多功能的细胞器，在细胞脂质和活性氧的代谢中起关键的协同作用。它们的功能相互作用，即“过氧化物酶体-线粒体连接”，还包括在抗病毒信号传导和防御方面的合作，以及通过共享关键分裂蛋白质而协调的生物发生。在这篇综述中，我们集中在哺乳动物的过氧化物酶体和线粒体共享的多定位蛋白。我们首先概述了参与代谢合作的基质蛋白的靶向和共享。接下来，我们讨论了过氧化物酶体和线粒体动力学和分裂的共同组成部分，我们提出了新的见解的双重靶向尾锚定膜蛋白。最后，我们提供了一个概述，目前已知的共享膜蛋白在疾病中的作用。出现的是，这两个细胞器之间的蛋白质共享在它们的合作功能中起着关键作用，根据新的发现，这可能比最初设想的更广泛。更好地了解细胞器的相互作用和共享蛋白质的靶向对于理解细胞器合作如何有助于人类健康和疾病至关重要。
Peroxisomes and mitochondria are dynamic, multifunctional organelles that play pivotal cooperative roles in the metabolism of cellular lipids and reactive oxygen species. Their functional interplay, the "peroxisome-mitochondria connection", also includes cooperation in anti-viral signalling and defence, as well as coordinated biogenesis by sharing key division proteins. In this review, we focus on multi-localised proteins which are shared by peroxisomes and mitochondria in mammals. We first outline the targeting and sharing of matrix proteins which are involved in metabolic cooperation. Next, we discuss shared components of peroxisomal and mitochondrial dynamics and division, and we present novel insights into the dual targeting of tail-anchored membrane proteins. Finally, we provide an overview of what is currently known about the role of shared membrane proteins in disease. What emerges is that sharing of proteins between these two organelles plays a key role in their cooperative functions which, based on new findings, may be more extensive than originally envisaged. Gaining a better insight into organelle interplay and the targeting of shared proteins is pivotal to understanding how organelle cooperation contributes to human health and disease.