Genetics of eating and its relation to obesity.
Genetics of eating and its relation to obesity.
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DOI：
10.1007/s11883-002-0017-3
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发表时间：
2002-05-01
影响因子：
5.8
通讯作者：
Faith, Myles S
中科院分区：
文献类型：
--
作者：
Keller, Kathleen L;Pietrobelli, Angelo;Faith, Myles S
人类在饮食方式上表现出显著的多样性。这种变异性的原因知之甚少，但对肥胖及其合并症的发病具有重要意义。虽然基因影响肥胖已经得到了很好的证实，但基因对人类饮食模式的影响却很少受到关注。肥胖流行率的急剧增加证明了对饮食方式遗传学的进一步研究是正确的。这篇综述强调了人类食物偏好和选择的遗传学知识。来自家庭和双胞胎研究的数据表明，饮食方式与遗传有一定的关系，同时也出现了明显的环境影响。选择研究表明支持基因-环境相互作用和某些饮食模式，肥胖症和/或代谢并发症的共同遗传基础。基因信息设计，注入创新的行为措施可能有助于解释饮食方式的个体差异，并有望促进更有效的肥胖治疗。
Humans show remarkable variability in their eating styles. Reasons for this variability are poorly understood, but carry important implications for the onset of obesity and its comorbidities. Although it is well established that genes influence obesity, genetic influences on human eating patterns have received less attention. Dramatic increases in the prevalence of obesity justify additional research into the genetics of eating style. This review highlights what is known about the genetics of food preferences and selection in humans. Data from family and twin studies suggest a moderate genetic contribution to eating style, with clear environmental effects emerging as well. Select studies show support for gene-environment interactions and common genetic bases for certain dietary patterns, obesity, and/or metabolic complications. Genetically informative designs that infuse innovative behavioral measures may help explain individual differences in eating styles and hopefully promote more effective obesity treatments.