Sirtuins as potential targets for metabolic syndrome
Sirtuins as potential targets for metabolic syndrome
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DOI：
10.1038/nature05486
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发表时间：
2006-12-14
期刊：
影响因子：
64.8
通讯作者：
Guarente, Leonard
中科院分区：
文献类型：
--
作者：
Guarente, Leonard
代谢综合征威胁着过去一个世纪所取得的健康成果。该综合征所导致的生理过程退化往往与热量限制产生相反的影响，热量限制可延长啮齿动物的寿命并预防疾病。衰老领域的近期研究已开始确定热量限制的重要介质，为研发改善健康寿命的新药带来了希望。此外，如果代谢综合征和热量限制处于同一代谢谱的两个相反极端，那么热量限制模拟物可能为代谢综合征提供另一种治疗方法。去乙酰化酶和其他影响热量限制的重要代谢途径可作为治疗代谢综合征药物的切入点。
Metabolic syndrome threatens health gains made during the past century. Physiological processes degraded by this syndrome are often oppositely affected by calorie restriction, which extends lifespan and prevents disease in rodents. Recent research in the field of ageing has begun to identify important mediators of calorie restriction, offering the hope of new drugs to improve healthspan. Moreover, if metabolic syndrome and calorie restriction are opposite extremes of the same metabolic spectrum, calorie restriction mimetics might provide another therapeutic approach to metabolic syndrome. Sirtuins and other important metabolic pathways that affect calorie restriction may serve as entry points for drugs to treat metabolic syndrome.