The relationship between methamphetamine and popper use and risk of HIV seroconversion in the Multicenter AIDS Cohort Study
The relationship between methamphetamine and popper use and risk of HIV seroconversion in the Multicenter AIDS Cohort Study
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DOI：
10.1097/qai.0b013e3180417c99
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发表时间：
2007-05-01
影响因子：
3.6
通讯作者：
Jacobson, Lisa P.
中科院分区：
文献类型：
--
作者：
Plankey, Michael W.;Ostrow, David G.;Jacobson, Lisa P.
背景资料：使用多中心艾滋病队列研究的纵向数据研究了男男性行为者（MSM）使用甲基苯丙胺与HIV血清转换之间的关系。方法：确定了1984年至1985年、1987年至1991年和2001年至2003年登记的血清阴性（n = 4003）男性。最近使用甲基苯丙胺和波普尔是在当前或上次访视时确定的。至HIV血清转换的时间是关注的结果。协变量包括人种/种族、队列、研究中心、教育水平、性伴侣数量、无保护插入性肛交伴侣数量、无保护接受性肛交伴侣数量、插入边缘。本次或末次访视时可卡因使用情况、本次或末次访视时摇头丸使用情况、自末次访视以来任何针头使用情况、自末次访视以来抑郁症流行病学研究中心症状自评量表评分> 16分以及饮酒情况。（95%置信区间[CI]：1.12至1.92）与甲基苯丙胺使用相关的HIV血清转化的相对危险性增加。与使用popper相关的相对危险度为2.10（95% CI：1.63 - 2.70）。HIV血清转化的相对危险性随着无保护的接受肛交性伴侣的数量而增加，范围从1个伴侣的1.87（95%CI：1.40至2.51）到5个+伴侣的9.32（95%CI：6.21至13.98）。甲基苯丙胺和波普尔使用的联合相对危险度为3-05（95%CI 2.12至4.37）。甲基苯丙胺的使用和未受保护的接受性肛交伴侣的数量有显著的联合相对危险，（95%CI：1.81 - 4.04），对于有1个无保护的肛交伴侣的男性，其增加的剂量依赖性方式为> 1个伴侣。进一步研究药物使用和性风险行为对艾滋病毒血清转换率协同作用的机制，对于制定新的针对非一夫一妻制艾滋病毒预防策略是必要的。吸毒的男男性接触者
Background: The association between methamphetamine use and HIV seroconversion for men who have sex with men (MSM) was examined using longitudinal data from the Multicenter AIDS Cohort StudyMethods: Seronegative (n = 4003) men enrolled in 1984 to 1985, 1987 to 1991, and 2001 to 2003 were identified. Recent methamphetamine and popper use was determined at the current or previous visit. Time to HIV seroconversion was the outcome of interest. Covariates included race/ethnicity, cohort, study site, educational level, number of sexual partners, number of unprotected insertive anal sexual partners, number of unprotected receptive anal sexual partners, insertive rimming.. cocaine use at the current or last visit, ecstasy use at the current or last visit, any needle use since the last visit, Center for Epidemiologic Study of Depression symptom checklist score > 16 since the last visit, and alcohol consumption.Results: After adjusting for covariates, there was a 1.46 (95% confidence interval [CI]: 1.12 to 1.92) increased relative hazard of HIV seroconversion associated with methamphetamine use. The relative hazard associated with popper use was 2.10 (95% CI: 1.63 to 2.70). The relative hazard of HIV seroconversion increased with the number of unprotected receptive anal sexual partners, ranging from 1.87 (95% CI: 1.40 to 2.51) for 1 partner to 9.32 (95% CI: 6.21 to 13.98) for 5+ partners. The joint relative hazard for methamphetarnine and popper use was 3-05 (95% CI 2.12 to 4.37). There was a significant joint relative hazard for methamphetamine use and number of unprotected receptive anal sexual partners of 2.71 (95% CI: 1.81 to 4.04) for men with 1 unprotected receptive anal sexual partner, which increased in a dose-dependent manner for > 1 partners.Conclusions: Further examination of the mechanisms underlying the synergism of drug use and sexual risk behaviors on rates of HIV seroconversion is necessary for the development of new targeted HIV prevention strategies for nonmonogamous drug-using MSM.