Molecular mechanisms of crystallization and defect formation
Molecular mechanisms of crystallization and defect formation
复制标题
结晶和缺陷形成的分子机制
DOI：
10.1103/physrevlett.85.353
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发表时间：
2000
影响因子：
8.6
通讯作者：
Vekilov
中科院分区：
文献类型：
--
作者：
Yau;Thomas;Vekilov
利用原子力显微镜(AFM)在蛋白质Apoferritin结晶过程中的原位观察，我们证明了对于这个体系来说，沿步骤的扭结密度是一个平衡性质，乘以分子的附着频率，完全决定了生长步骤的传播。分子间的键能为3.2K(B)T。点缺陷是非平衡的，由杂质分子的掺入引起，并由于它们引起的应变而在随后的层中复制。利用原子力显微镜针尖的单分子操纵，可以修复缺陷，恢复规则的晶格。
Using the atomic force microscope (AFM) in situ during the crystallization of the protein apoferritin, we show that for this system the kink density along the steps is an equilibrium property that, multiplied by the frequency of molecular attachment, fully determines the propagation of growth steps. The intermolecular bond energy is 3.2k(B)T. Point defects are nonequilibrial and are caused by incorporation of impurity molecules, and replicate in subsequent layers due to the strain they cause. Using single-molecule manipulation with the AFM tip, the defects can be healed to restore the regular lattice.