Regenerative Medicine: Advances from Developmental to Degenerative Diseases
Regenerative Medicine: Advances from Developmental to Degenerative Diseases
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DOI：
10.1007/978-3-319-60733-7_12
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Barbaric, Ivana
中科院分区：
文献类型：
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作者：
Blair, Nicholas F.;Frith, Thomas J. R.;Barbaric, Ivana
由损伤、疾病、衰老或先天性缺陷引起的慢性组织和器官衰竭代表了一些最复杂的治疗挑战，并造成了重大的经济医疗负担。再生医学策略旨在通过刺激内源性组织修复或通过使用移植策略替换缺失或有缺陷的细胞来恢复正常组织功能，从而满足未满足的临床需求。干细胞代表了再生医学工作的重要支柱，因为它们提供了用于细胞替代疗法的祖细胞或分化细胞的来源。虽然在控制干细胞命运并将其分化为感兴趣的细胞类型方面取得了重大飞跃，但将定制的细胞产品从学术环境过渡到现成的临床治疗带来了一系列全新的挑战，包括制造，监管和资金问题。尽管在细胞替代疗法使全球医疗保健受益之前需要解决这些问题，但该领域的不断进步突出了再生医学作为治疗一些以前无法治愈的疾病的现实前景。
Chronic tissue and organ failure caused by an injury, disease, ageing or congenital defects represents some of the most complex therapeutic challenges and poses a significant financial healthcare burden. Regenerative medicine strategies aim to fulfil the unmet clinical need by restoring the normal tissue function either through stimulating the endogenous tissue repair or by using transplantation strategies to replace the missing or defective cells. Stem cells represent an essential pillar of regenerative medicine efforts as they provide a source of progenitors or differentiated cells for use in cell replacement therapies. Whilst significant leaps have been made in controlling the stem cell fates and differentiating them to cell types of interest, transitioning bespoke cellular products from an academic environment to off-the-shelf clinical treatments brings about a whole new set of challenges which encompass manufacturing, regulatory and funding issues. Notwithstanding the need to resolve such issues before cell replacement therapies can benefit global healthcare, mounting progress in the field has highlighted regenerative medicine as a realistic prospect for treating some of the previously incurable conditions.