Neutralizing antibody responses to enterovirus and adenovirus in healthy adults in China.
Neutralizing antibody responses to enterovirus and adenovirus in healthy adults in China.
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在中国健康成年人中，中和对肠病毒和腺病毒的抗体反应。
DOI：
10.1038/emi.2014.30
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发表时间：
2014-05
影响因子：
13.2
通讯作者：
Zhou, Dongming
中科院分区：
文献类型：
--
作者：
Wang, Xiang;Xing, Man;Zhang, Chao;Yang, Yong;Chi, Yudan;Tang, Xinying;Zhang, Hongbo;Xiong, Sidong;Yu, Luogang;Zhou, Dongming
手足口病（HFMD）是过去几年出现的一个重要公共卫生问题。手足口病主要感染7岁以下儿童，偶尔会在成人中引起严重疾病。在肠道病毒中，肠道病毒71型（EV 71）和柯萨奇病毒16型（CA 16）是手足口病的主要病原体。此外，腺病毒与肠道病毒共循环，在某些情况下可能成为手足口病的额外致病因素。在这里，我们调查了中和抗体反应，肠道病毒和腺病毒在成人中，探索这些病毒的流行趋势和保护性免疫的性质，在这些病毒感染的人类的目的。采用中和试验检测了来自中国21个省市的391名健康成人血清中的EV 71、CA 16、人血清5型腺病毒（AdHu 5）和黑猩猩腺病毒pan 7（AdC 7）抗体。人群中EV 71、CA 16和AdHu 5阳性率较高，分别为85.7%、58.8%和74.2%。这三种病毒的共血清阳性率为39.4%（154/391），中和抗体滴度中位数分别为80、40和640，EV 71的中和抗体滴度与CA 16和AdHu 5的中和抗体滴度相关。发现AdC 7是人群中罕见的腺病毒血清型，血清阳性率为11.8%，这表明它可能是可用于疫苗开发的疫苗载体的良好选择。
Hand, foot and mouth disease (HFMD) is an important public health problem that has emerged over the past several years. HFMD predominantly infects children under seven years old and occasionally causes severe disease in adults. Among the enteroviruses, enterovirus 71 (EV71) and coxsackievirus 16 (CA16) are the major causative agents of HFMD. In addition, adenovirus cocirculates with enterovirus and has become a possible additional pathogenic factor for HFMD in some cases. Here, we have investigated the neutralizing antibody responses to both enterovirus and adenovirus in adults, with the aim of exploring the prevalence trends of these viruses and the nature of protective immunity in humans to these viral infections. Sera from 391 healthy adults from 21 provinces and cities in China were tested for the presence of antibodies against EV71, CA16, adenovirus human serotype 5 (AdHu5) and chimpanzee adenovirus pan7 (AdC7) using neutralization tests. High seroprevalence rates of EV71, CA16 and AdHu5 were found in the population (85.7%, 58.8% and 74.2%, respectively). The coseropositivity rate of these three viruses was 39.4% (154 of 391), with median neutralizing antibody titers of 80, 40 and 640, respectively, and the neutralizing antibody titer for EV71 was found to be correlated with those of CA16 and AdHu5. AdC7 was found to be a rare adenovirus serotype in the human population, with a seropositivity rate of 11.8%, suggesting that it could be a good choice for a vaccine carrier that could be used in vaccine development.
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影响因子：
3.7
作者：
Ku Z;Ye X;Huang X;Cai Y;Liu Q;Li Y;Su Z;Huang Z
通讯作者：
Huang Z
DOI：
10.1128/cdli.11.2.351-357.2004
发表时间：
2004-03-01
期刊：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
影响因子：
--
作者：
Nwanegbo, E;Vardas, E;Gambotto, A
通讯作者：
Gambotto, A
DOI：
10.1073/pnas.26.1.1
发表时间：
1940-01-01
影响因子：
11.1
作者：
Davenport, CB
通讯作者：
Davenport, CB
影响因子：
9.4
作者：
Thorner, Anna R.;Vogels, Ronald;Barouch, Dan H.
通讯作者：
Barouch, Dan H.
影响因子：
5.5
作者：
Kobinger GP;Figueredo JM;Rowe T;Zhi Y;Gao G;Sanmiguel JC;Bell P;Wivel NA;Zitzow LA;Flieder DB;Hogan RJ;Wilson JM
通讯作者：
Wilson JM