Quantification of regional cerebral blood flow and vascular reserve in childhood Moyamoya disease using [I-123]IMP-ARG method
Quantification of regional cerebral blood flow and vascular reserve in childhood Moyamoya disease using [I-123]IMP-ARG method
复制标题
DOI：
10.1016/s0303-8467(97)00065-6
复制
发表时间：
1997-10-01
影响因子：
1.9
通讯作者：
Nakamura, J
中科院分区：
文献类型：
--
作者：
Nakagawara, J;Takeda, R;Nakamura, J
应用单光子发射计算机断层扫描(SPECT)和N-异丙基-Rho-碘苯丙胺(IMP-ARG)放射自显影技术对10例儿童烟雾病患者手术前后的局部脑血流量(RCBF)和局部血管储备(RVR)进行定量，以评价手术血运重建的血流动力学效果。2例术前rCBF下降，前循环RVR丢失，大脑前动脉(ACA)+4.3%，大脑中动脉(MCA)-3.0%，大脑后动脉(PCA)+17.5%。术后8例无短暂性脑缺血发作(TIA)患者，全区静息rCBF维持在低于正常水平，ACA区、MCA区和PCA区RVR分别为+11.9%、+17.3%和+28.3%。而前循环的RVR明显低于后循环的RVR。用IMP-ARG方法定量测定静息rCBF和RVR可为儿童烟雾病的手术指征和疗效提供可靠的信息。(C)1997年爱思唯尔科学公司。
Both regional cerebral blood flow (rCBF) and regional vascular reserve (rVR) in ten childhood Moyamoya disease were quantified pre-and post-operatively by autoradiographic processing using single photon emission computed tomography (SPECT) and N-isopropyl-rho-iodoamphetamine (IMP) (IMP-ARG method) to estimate hemodynamic effectiveness of surgical revascularization. Before surgery, in two patients, rCBF was reduced in the whole territories and loss of rVR in the anterior circulation was observed; +4.3% in the anterior cerebral artery (ACA), -3.0% in the middle cerebral artery (MCA) and +17.5% in posterior cerebral artery (PCA) territories. After surgery, in eight patients without transient ischemic attack (TIA) episodes, rCBF at rest was maintained around subnormal level in the whole territories, and mean rVR was up to +11.9, +17.3 and +28.3% in ACA, MCA and PCA territories, respectively. However, rVR in the anterior circulation was significantly reduced in comparison with rVR in the posterior circulation. Quantification of both resting rCBF and rVR using IMP-ARG method could provide reliable information concerning on surgical indication and its effectiveness in childhood Moyamoya disease. (C) 1997 Elsevier Science B.V.