Highly pathogenic avian influenza virus (H5N1) in experimentally infected adult mute swans
Highly pathogenic avian influenza virus (H5N1) in experimentally infected adult mute swans
复制标题
DOI：
10.3201/eid1408.080078
复制
发表时间：
2008-08-01
影响因子：
11.8
通讯作者：
Beer, Martin
中科院分区：
文献类型：
--
作者：
Kalthoff, Donata;Breithaupt, Angele;Beer, Martin
成年健康疣鼻天鹅实验性感染高致病性禽流感病毒A/Cygnus cygnus/Germany/R65/2006亚型H5N1。免疫学上幼稚的鸟类死亡，而预先存在的、自然获得的禽流感病毒特异性抗体的动物则无症状感染并传播病毒。成年疣鼻天鹅高度易感，能排泄病毒，临床上可通过暴露前免疫得到保护。
Adult, healthy mute swans were experimentally infected with highly pathogenic avian influenza virus A/Cygnus cygnus/Germany/R65/2006 subtype H5N1. Immunologically naive birds died, whereas animals with preexisting, naturally acquired avian influenza virus-specific antibodies became infected asymptomatically and shed virus. Adult mute swans are highly susceptible, excrete virus, and can be clinically protected by preexposure immunity.