Nutritional support in allogeneic hematopoietic stem cell transplantation Asian perspective.
Nutritional support in allogeneic hematopoietic stem cell transplantation Asian perspective.
复制标题
异基因造血干细胞移植中的营养支持。
DOI：
10.31547/bct-2021-024
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发表时间：
2022-05-25
期刊：
影响因子：
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通讯作者：
Wanitpongpun, Chinadol
中科院分区：
文献类型：
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作者：
Fuji, Shigeo;Cheng, Jessica;Yakushijin, Kimikazu;Wanitpongpun, Chinadol
同种异体造血干细胞移植（Allogeneic hematopoietic stem cell transplantation, alloo - hsct）是恶性或非恶性血液病治疗策略的重要组成部分。近几十年来，接受同种异体造血干细胞移植的患者的临床结果有了显著改善。然而，移植相关的发病率和死亡率仍然是同种异体造血干细胞移植接受者的主要问题。在营养方面，接受同种异体造血干细胞移植的患者营养不良的风险很高。近几十年来，关于同种异体造血干细胞移植中营养支持的临床实践有望得到改善；然而，没有数据直接支持这一预期。在同种异体造血干细胞移植期间管理营养支持的一个主要问题是缺乏大规模随机前瞻性研究，这导致缺乏完善的策略。因此，我们需要从非hsct和允许hsct的研究中收集数据。在一些亚太国家，医生缺乏营养支持知识可能会阻碍现有指南所推荐的营养支持实践的应用。另一个障碍可能是在全造血干细胞移植单位缺乏足够资格或训练有素的注册营养师（RD）。应向所有从事造血干细胞移植的研发人员提供同种异体移植患者营养管理方面的充分培训。在此，我们总结了关于异体造血干细胞移植的营养支持的信息，重点是亚洲的观点。
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an integral part of the treatment strategy for patients with malignant or non-malignant hematological diseases. Clinical outcomes of patients undergoing allo-HSCT have significantly improved in recent decades. However, transplant-related morbidity and mortality remain major issues for allo-HSCT recipients. With regard to nutrition, patients undergoing allo-HSCT are at high risk for malnutrition. It is expected that clinical practice concerning nutritional support in allo-HSCT has been improving in recent decades; however, no data directly support this expectation. One major issue in managing nutritional support during allo-HSCT is the lack of large-scale randomized prospective studies, which leads to a lack of well-established strategies. Accordingly, we need to gather data from studies in non-HSCT and allo-HSCT settings. In some Asia-Pacific countries, a physician's lack of knowledge of nutritional support may impede the application of nutritional support practices recommended by existing guidelines. Another barrier may be the lack of access to an adequately qualified or trained registered dietitian (RD) at allo-HSCT units. Adequate training in the nutritional management of allo-HSCT patients should be provided to all RDs working with HSCT. Herein, we summarize the information on nutritional support in allo-HSCT, focusing on an Asian perspective.