A comparison of cognitive impairment due to benzodiazepines and to narcotics.
A comparison of cognitive impairment due to benzodiazepines and to narcotics.
复制标题
苯二氮卓类药物和麻醉剂引起的认知障碍的比较。
DOI：
10.1176/ajp.137.7.828
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
D. Long
中科院分区：
文献类型：
--
作者：
N. Hendler;Cindi Cimini;Terence Ma;D. Long
为了确定106名连续入住约翰霍普金斯慢性疼痛治疗中心的患者的认知障碍的来源，我们使用了脑电图、韦氏成人智力量表、记忆商和本德格式塔测试。单独接受苯二氮卓类药物治疗的患者表现出认知功能的改变和镇静作用的脑电图证据。单独接受麻醉品治疗的患者和一组不接受药物治疗的患者没有表现出认知障碍的迹象。苯二氮卓类药物对睡眠和慢性疼痛感知的影响，以及它们产生的皮质变化，暗示这些药物不应该用于大多数慢性疼痛患者。
In an attempt to determine the source of cognitive impairment in 106 consecutively admitted patients at the Johns Hopkins Chronic Pain Treatment Center, EEG, the Wechsler Adult Intelligence Scale, Memory Quotient, and Bender Gestalt tests were administered. Patients receiving benzodiazepines alone demonstrated alterations in cognitive functioning and EEG evidence of a sedative effect. Patients receiving narcotics alone and a group of patients not receiving medication did not show signs of cognitive impairment. The effects of benzodiazepines on sleep and perception of chronic pain, in combination with the cortical changes that they produce, imply that these drugs should not be used in most patients with chronic pain.