APOLIPOPROTEIN EPSILON-4 ALLELE AND DISEASE PROGRESSION IN PATIENTS WITH LATE-ONSET ALZHEIMERS-DISEASE
APOLIPOPROTEIN EPSILON-4 ALLELE AND DISEASE PROGRESSION IN PATIENTS WITH LATE-ONSET ALZHEIMERS-DISEASE
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DOI：
10.1016/0304-3940(94)11107-t
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发表时间：
1995-01-02
影响因子：
2.5
通讯作者：
LANNFELT, L
中科院分区：
文献类型：
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作者：
BASUN, H;GRUT, M;LANNFELT, L
从人群中随机抽取60例晚发性阿尔茨海默病（AD）患者，间隔3年进行载脂蛋白E（apoE）基因分型和临床检查。与非等位基因携带者相比，等位基因携带者的发病年龄明显较低。然而，在第一次检查时，尽管携带者的病程较长，但携带者和非携带者之间的简易精神状态检查（MMSE）测试分数没有显著差异。3年后，携带者和非携带者之间的MMSE测试分数仍然没有显着差异，但非携带者死亡人数是非携带者的两倍多。所有其他临床特征在携带者和非携带者之间相似。这项研究表明，在晚发性AD中，等位基因E14与疾病的较好预后相关，但可能存在除了E14等位基因之外的对AD表型重要的因素。
A random sample of 60 late-onset Alzheimer's disease (AD) cases from a population-based study were apolipoprotein E (apoE) genotyped and clinically examined with a 3-year interval. The epsilon 4 allele carriers had a significantly lower age of disease onset compared to non-epsilon 4 carriers. However, no significant differences were observed between epsilon 4 allele carriers and non-carriers for Mini-Mental State Examination (MMSE) test scores at the first examination, in spite of a longer disease duration in the epsilon 4 allele carriers. After 3 years, MMSE test scores were still not significantly different between epsilon 4 carriers and non-carriers but more than twice as many non-carriers had died. All other clinical features were similar between epsilon 4 allele carriers and non-carriers. This study indicates that the epsilon 4 allele is associated with a better prognosis of the disease in late-onset AD but that there are probably factors other than the epsilon 4 allele that are important for the AD phenotype.