Structure and function of nucleosome assembly proteins
Structure and function of nucleosome assembly proteins
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DOI：
10.1139/o06-088
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发表时间：
2006-08-01
影响因子：
2.9
通讯作者：
Luger, Karolin
中科院分区：
文献类型：
--
作者：
Park, Young-Jun;Luger, Karolin
核小体组装蛋白1（NAP1）的同源物已在所有真核生物中鉴定。虽然最初被鉴定为组蛋白伴侣和染色质组装因子，其他功能包括在组织特异性转录调节，细胞凋亡，组蛋白穿梭和细胞周期调节中的作用，并超出了简单的伴侣和组装因子。NAP1家族成员共有一个结构保守的折叠，NAP结构域。在这里，我们审查目前的知识NAP家族的蛋白质的背景下，最近确定的晶体结构的NAP 1家族的第一个代表，NAP 1从酵母。
Homologues of nucleosome assembly protein 1 (NAP1) have been identified in all eukaryotes. Although initially identified as histone chaperones and chromatin-assembly factors, additional functions include roles in tissue-specific transcription regulation, apoptosis, histone shuttling, and cell-cycle regulation, and extend beyond those of a simple chaperone and assembly factor. NAP1 family members share a structurally conserved fold, the NAP domain. Here we review current knowledge of the NAP family of proteins within the context of the recently determined crystal structure of the NAP1 familys first representative, NAP1 from yeast.