The role of Caenorhabditis elegans insulin-like signaling in the behavioral avoidance of pathogenic Bacillus thuringiensis
The role of Caenorhabditis elegans insulin-like signaling in the behavioral avoidance of pathogenic Bacillus thuringiensis
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DOI：
10.1096/fj.06-6551com
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发表时间：
2007-06-01
期刊：
影响因子：
4.8
通讯作者：
Schulenburg, Hinrich
中科院分区：
文献类型：
--
作者：
Hasshoff, Martin;Boehnisch, Claudia;Schulenburg, Hinrich
病原体会造成损害，消除它们需要激活昂贵的免疫反应。因此，一个高度经济的防御策略应该是对病原体的行为回避，就像人类对卫生的各个方面或对富含病原体的物质的厌恶一样。尽管行为防御具有潜在的重要性，但它在生物医学研究中却很少受到关注，这与生理免疫系统形成了鲜明的对比。在本研究中，这种行为防御的遗传学阐明了一个简单的模式生物，线虫秀丽隐杆线虫。我们首次表明，胰岛素样受体（ILR）途径的突变导致两种不同的行为反应，对革兰氏阳性细菌苏云金芽孢杆菌（BT）的致病菌株，包括病原体的物理逃避和减少口服摄入。由于这一途径也有助于线虫胁迫抗性，结果令人惊讶地揭示了生理和行为防御之间的遗传联系。考虑到许多信号通路在进化过程中保留了它们的功能，包括ILR通路，这种信号级联可能代表了更复杂生物（包括人类）行为防御的有趣候选调节因子。Hashoff M.，Bohnisch C. Tonn D. Hasert B.，舒伦堡湾秀丽隐杆线虫胰岛素样信号在致病性苏云金杆菌行为回避中的作用。
Pathogens cause damage, and their elimination requires activation of the costly immune response. A highly economic defense strategy should thus be the behavioral avoidance of pathogens, as manifested in humans by all aspects of hygiene or revulsion at pathogen-rich material. Despite its potential importance, behavioral defenses have as yet received only little attention in biomedical research-in stark contrast to the physiological immune system. In the present study, the genetics of such behavioral defenses are elucidated in a simple model organism, the nematode Caenorhabditis elegans. We show for the first time that mutations in the insulin-like receptor (ILR) pathway lead to two distinct behavioral responses against pathogenic strains of the Gram-positive bacterium Bacillus thuringiensis ( BT), including the physical evasion of pathogens and their reduced oral uptake. Since this pathway also contributes to nematode stress resistance, the results surprisingly reveal a genetic link between physiological and behavioral defenses. Considering that many signaling pathways have conserved their functions across evolution, including the ILR pathway, this signaling cascade may represent an interesting candidate regulator for behavioral defenses in more complex organisms, including humans.-Hasshoff M., Bohnisch C., Tonn D., Hasert B., Schulenburg H. The role of Caenorhabditis elegans insulin-like signaling in the behavioral avoidance of pathogenic Bacillus thuringiensis.