Micro-injection studies of capillary permeability II. The relation between capillary pressure and the rate at which fluid passes through the walls of single capillaries
Micro-injection studies of capillary permeability II. The relation between capillary pressure and the rate at which fluid passes through the walls of single capillaries
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DOI：
10.1152/ajplegacy.1927.82.2.217
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发表时间：
1927-10-01
影响因子：
--
通讯作者：
Landis, EM
中科院分区：
文献类型：
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作者：
Landis, EM
通过显微注射方法，可以测量蛙肠系膜单个毛细血管的血压，将染料注射到不同直径的毛细血管中，并直接测量流体通过毛细血管壁的运动速率。将染料溶液注入蛙肠系膜的单个毛细血管表明，扩张的毛细血管壁的渗透性并不比收缩的血管壁的渗透性强。染料溶液通过毛细管壁的速度取决于毛细管压力的大小，而不取决于毛细管直径。在任何给定的压力下，不同的染料溶液在可见光通过所需的时间上明显不同，这可能是由于它们不同的胶体性质。就染料的渗透性而言，将火棉胶制成的毛细血管与肠系膜毛细血管进行比较是不合理的。引入心室血液的活力红HR立即通过压力高于14 cm的毛细血管壁。水，但保留了一些分钟。在压力低于11厘米。直接测量表明，通过毛细血管壁的流体运动速率与毛细血管压力和血浆蛋白的渗透压之间的差成正比，约为0.03立方微米/平方厘米。微米毛细管壁/秒相差5厘米。水压。如该方法所示，血浆蛋白对其天然膜的渗透压为11.5 cm。水当毛细管压力超过该值时，发生过滤;当它福尔斯低于该值时，发生吸收。酒精和氯化汞损伤的毛细血管似乎是血浆胶体的渗透性和约7倍以上的液体比正常毛细血管壁的渗透性。
By micro-injection methods it has been possible to measure blood pressures in single capillaries of the frog''s mesentery, to inject dyes into capillaries of various diam., and to measure directly the rate of movement of fluid through the capillary wall. Introduction of dye solutions into single capillaries of the frog''s mesentery indicates that the walls of dilated capillaries are not more permeable than those of constricted vessels. Rate of passage of a dye solution through the capillary wall depends upon the level of capillary pressure, not upon capillary diam. At any given pressure various dye solutions differ markedly in the time required for visible passage, due probably to their different colloidal properties. So far as permeability to dyes is concerned, comparison of capillaries made of collodion to the mesenteric capillaries is not justified. Vital red HR introduced into the ventricular blood passes immediately through the walls of those capillaries whose pressure is above 14 cm. of water, but is retained for some min. at pressures below 11 cm. Direct measurement shows the rate of fluid movement through the capillary wall to be directly proportional to the difference between capillary pressure and the osmotic pressure of the plasma proteins, amounting to approximately 0.03 cubic micra per sq. micron of capillary wall per sec. for a difference of 5 cm. water pressure. The osmotic pressure of the plasma proteins against their natural membrane as indicated by this method is 11.5 cm. water. When capillary pressure exceeds this value, filtration occurs; when it falls below it absorption results. Capillaries injured by alcohol and HgCl2 appear to be permeable to the plasma colloids and approximately 7 times more permeable to fluid than the normal capillary wall.