Assessment of brain metastases with dynamic susceptibility-weighted contrast-enhanced MR imaging: Initial results
Assessment of brain metastases with dynamic susceptibility-weighted contrast-enhanced MR imaging: Initial results
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DOI：
10.1148/radiol.2281020298
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发表时间：
2003-07-01
期刊：
影响因子：
19.7
通讯作者：
Knopp, MV
中科院分区：
文献类型：
--
作者：
Essig, M;Waschkies, M;Knopp, MV
目的：评价放疗前和早期随访局部脑血容量(CBV)是否有助于预测脑转移瘤患者的治疗结果，以及评价放疗后肿瘤和正常组织局部CBV的变化。材料和方法：对18例患者进行动态磁化率加权对比剂增强磁共振(MR)成像，使用1.5T单元，对局部CBV进行绝对量化。在治疗前、治疗后6周和3个月进行测量：根据治疗6个月时肿瘤体积的变化对治疗结果进行分类：用感兴趣区分析确定转移灶和正常邻近脑组织的局部CBV。结果：治疗前局部CBV值不能帮助预测治疗结果，但该方法对6周随访时的治疗结果预测具有高度的敏感性和特异性。局部：CBV值的降低有助于预测治疗结果，敏感性超过9000：仅肿瘤体积变化的敏感性仅为%。测量的正常脑组织的局部CBV值及其比值与生理数据相当，并保持不变。结论：动态磁化率加权增强磁共振成像是评估放射外科治疗脑转移瘤的一种有用的方法。实施的技术与动脉输入功能的确定实现了区域CBV的绝对量化和对肿瘤反应的预测。(C)RSNA，2003年。
Purpose: To assess if preradiaton and early follow-up regional cerebral blood volume (CBV) measurements can help predict treatment outcome in patients with cerebral metastases and to evaluate regional CBV changes in tumor and normal tissue after radiosurgery.Materials and Methods: In 18 patients, dynamic susceptibility-weighted contrast material-enhanced magnetic resonance (MR) imaging was performed with a 1.5-T unit, which allowed an absolute quantification of the regional CBV. Measurements were performed prior to and at 6 weeks and 3 months after therapy: Treatment outcome was classified according to tumor volume changes at 6 months: The regional CBV of the metastases and the normal adjacent brain tissue were determined with a region-of-interest analysis. Regional CBV values were correlated with the patient outcome to assess the sensitivity and specificity of dynamic susceptibility-weighted contrast-enhanced MR imaging.Results: The pretherapeutic regional CBV was not able to help predict a treatment outcome; however; the method proved to be highly sensitive and specific for : treatment outcome prediction at the 6-week follow-up. A decrease of the regional : CBV value helped predict the treatment outcome with a sensitivity of more than 9000: The tumor volume change alone had a sensitivity of only 64%. The measured regional CBV values of normal brain tissue and their ratio were comparable to physiologic data and remained. unchanged with therapy.Conclusion: The results suggest that dynamic susceptibility-weighted contrast-enhanced MR imaging is a useful method for the assessment of radiosurgically treated brain metastases. The implemented technique with determination of the arterial input function enables an absolute quantification of the regional CBV and prediction of tumor response. (C) RSNA, 2003.