The Epigenome and Beyond: How Does Non-genetic Inheritance Change Our View of Evolution?
The Epigenome and Beyond: How Does Non-genetic Inheritance Change Our View of Evolution?
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DOI：
10.1093/icb/icab084
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发表时间：
2022-02-05
影响因子：
2.6
通讯作者：
Riddle, Nicole C.
中科院分区：
文献类型：
--
作者：
Brodie, Edmund D., III;Gregory, Brian;Riddle, Nicole C.
来自生命之树的证据表明，表观遗传比以前认为的更常见。如果表观遗传真的像数据显示的那样普遍，那么这一发现对进化理论以及我们对进化和适应过程的理解具有潜在的重要意义。然而，我们目前缺乏对各种表观遗传类型有多常见以及它们如何影响表型的理解。从这个角度来看，我们审查了开放的问题，需要解决的表观遗传完全整合到进化理论和发展可靠的预测模型的表型进化。我们认为，应对这些挑战将需要来自不同学科的生物学家的合作，并专注于对数据和现象的探索，而不对潜在机制或结果进行先入为主的限制。
Evidence from across the tree of life suggests that epigenetic inheritance is more common than previously thought. If epigenetic inheritance is indeed as common as the data suggest, this finding has potentially important implications for evolutionary theory and our understanding of how evolution and adaptation progress. However, we currently lack an understanding of how common various epigenetic inheritance types are, and how they impact phenotypes. In this perspective, we review the open questions that need to be addressed to fully integrate epigenetic inheritance into evolutionary theory and to develop reliable predictive models for phenotypic evolution. We posit that addressing these challenges will require the collaboration of biologists from different disciplines and a focus on the exploration of data and phenomena without preconceived limits on potential mechanisms or outcomes.