Five-year results following treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration
Five-year results following treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration
复制标题
DOI：
10.1111/j.1600-051x.2004.00518.x
复制
发表时间：
2004-07-01
影响因子：
6.7
通讯作者：
Arweiler, NB
中科院分区：
文献类型：
--
作者：
Sculean, A;Donos, N;Arweiler, NB
背景：用釉质基质蛋白（EMD）或引导组织再生（GTR）治疗已被证明可促进牙周再生。然而，到目前为止，关于这些治疗方法的长期结果的数据有限。目的：本临床研究的目的是介绍使用EMD、GTR、EMD和GTR联合治疗骨内缺损以及开放皮瓣清创术（OFD）治疗骨内缺损的5年结果。材料和方法：42例患者，每个人都显示一个骨内缺损的探测深度至少为6毫米，随机治疗的四种治疗方式之一。在术前、术后1年和术后5年评价了以下参数：菌斑指数、牙龈指数、探诊出血、探诊袋深度（PPD）、牙龈退缩和临床附着水平（CAL）。结果：EMD治疗的部位在1年和5年的平均CAL增益分别为3.4 ± 1.1 mm（p < 0.001）和2.9 ± 1.6 mm（p < 0.001）。用GTR治疗的部位显示，1年时的平均CAL增益为3.2 ± 0.8（p < 0.001），5年时为2.7 ± 0.9 mm（p < 0.001）。在1年和5年时，EMD + GTR治疗部位的平均CAL增益分别为3.0 ± 1.0 mm（p < 0.001）和2.6 ± 0.7 mm（p < 0.001）。用OFD治疗的部位显示，1年时的平均CAL增益为1.6 ± 1.0 mm（p < 0.001），5年时为1.3 ± 1.2 mm（p < 0.001）。在第1年，四种不同治疗之间的唯一统计学显著差异是EMD和OFD之间PPD减少和CAL增加（p
Background: Treatment with enamel matrix proteins (EMD) or guided tissue regeneration (GTR) has been shown to enhance periodontal regeneration. However, until now there are limited data on the long-term results following these treatment modalities.Aim: The aim of the present clinical study was to present the 5-year results following treatment of intrabony defects with EMD, GTR, combination of EMD and GTR, and open flap debridement (OFD).Material and Methods: Forty-two patients, each of whom displayed one intrabony defect of a probing depth of at least 6 mm, were randomly treated with one of the four treatment modalities. The following parameters were evaluated prior to surgery, at 1 year and at 5 years after: plaque index, gingival index, bleeding on probing, probing pocket depth (PPD), gingival recession, and clinical attachment level (CAL). No statistically significant differences in any of the parameters were observed at baseline between the four groups.Results: The sites treated with EMD demonstrated a mean CAL gain of 3.4 +/- 1.1 mm (p < 0.001) and of 2.9 +/- 1.6 mm (p < 0.001) at 1 and 5 years, respectively. The sites treated with GTR showed a mean CAL gain of 3.2 +/- 0.8 (p < 0.001) at 1 year and of 2.7 +/- 0.9 mm (p < 0.001) at 5 years. The mean CAL gain at sites treated with EMD + GTR was 3.0 +/- 1.0 mm (p < 0.001) and 2.6 +/- 0.7 mm (p < 0.001) at 1 and 5 years, respectively. The sites treated with OFD demonstrated a mean CAL gain of 1.6 1.0 mm (p < 0.001) at 1 year and 1.3 +/- 1.2 mm (p < 0.001) at 5 years. At I year, the only statistically significant difference between the four different treatments was found in terms of PPD reduction and CAL gain between EMD and OFD (p