Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice
Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice
复制标题
脂肪细胞特异性 Nfe2l1 缺陷会破坏小鼠白色脂肪组织的可塑性和代谢稳态
DOI：
10.1016/j.bbrc.2018.06.013
复制
发表时间：
2018-09-03
影响因子：
3.1
通讯作者：
Pi, Jingbo
中科院分区：
文献类型：
--
作者：
Hou, Yongyong;Liu, Zhiyuan;Pi, Jingbo
维持健康的脂肪组织是有效调节能量稳态的必要条件。核因子-红细胞2相关因子1 （Nuclear factor-erythroid 2-related factor 1, NFE2L1，又称Nrf1）是一种CNC-bZIP蛋白，是细胞适应应激反应的主要调控因子。为了研究NFE2L1在脂肪细胞中的作用，我们培育了一种脂肪细胞特异性NFE2L1敲除（NFE2L1 (f)-KO）的小鼠，发现NFE2L1 (f)-KO小鼠表现出皮下脂肪组织（SAT）质量显著降低、胰岛素抵抗、脂肪细胞肥大和严重的脂肪炎症。机制研究表明，缺乏Nfe2l1可能干扰脂肪细胞中脂溶基因的表达，导致脂肪细胞肥大，随后出现炎症、焦亡和胰岛素抵抗。我们的发现揭示了NFE2L1在调节脂肪组织可塑性和能量稳态中的新作用。(C) 2018爱思唯尔公司版权所有。
The maintenance of healthy adipose tissues is essential for efficient regulation of energy homeostasis. Nuclear factor-erythroid 2-related factor 1 (NFE2L1, also known as Nrf1), a CNC-bZIP protein, is a master regulator of the cellular adaptive response to stresses. To investigate the role of NFE2L1 in adipocytes, we bred a line of mice with adipocyte-specific Nfe2l1 knockout (Nfe2l1(f)-KO), and found that Nfe2l1(f)-KO mice exhibited a dramatically reduced subcutaneous adipose tissue (SAT) mass, insulin resistance, adipocyte hypertrophy, and severe adipose inflammation. Mechanistic studies revealed that Nfe2l1 deficiency may disturb the expression of lipolytic genes in adipocytes, leading to adipocyte hypertrophy followed by inflammation, pyroptosis, and insulin resistance. Our findings reveal a novel role for NFE2L1 in regulating adipose tissue plasticity and energy homeostasis. (C) 2018 Elsevier Inc. All rights reserved.