Aging or tumor: the crosstalk between telomerase and p53
Aging or tumor: the crosstalk between telomerase and p53
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DOI：
10.3724/sp.j.1005.2009.00451
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发表时间：
2009-05-01
期刊：
影响因子：
--
通讯作者：
Luo Ying
中科院分区：
文献类型：
--
作者：
Zhang Xiu-Feng;Tang Wen-Ru;Luo Ying
端粒酶和P53在肿瘤的发生和衰老中起关键作用。在大多数人类肿瘤中都发现了P53基因的突变和端粒酶的重新激活。靶向端粒酶和p53基因已成为肿瘤治疗的重要策略。我们综述了端粒酶和P53不同状态下的衰老和肿瘤表型(MTR(-/-)P53(+/+)；MTR(-/-)P53(-/-))，提示端粒功能障碍可以启动或抑制肿瘤的发生，这取决于P53的状态。这有助于进一步了解P53和端粒酶在衰老和肿瘤发生中的相互作用，并为肿瘤的治疗提供新的思路。
Telomerase and p53 play critical roles in tumorigenesis and senescence. The mutation of p53 gene and the reactivation of telomerase have been found in most of the human tumors. Aiming telomerase and p53 genes have become important strategies in tumor therapy. We reviewed the aging and tumor phenotype in different status of telomerase and p53 (mTR(-/-)p53(+/+); mTR(-/-)P53(-/-)), which indicated that telomere dysfunction could initiate or suppress the tumorigenesis depending on the status of p53. This helps further understanding of the crosstalk between p53 and telomerase in aging and tumorigenesis, and provides a new idea for treating tumor.