Small extracellular vesicle non-coding RNAs in pancreatic cancer: molecular mechanisms and clinical implications.
Small extracellular vesicle non-coding RNAs in pancreatic cancer: molecular mechanisms and clinical implications.
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DOI：
10.1186/s13045-021-01149-4
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发表时间：
2021-09-08
影响因子：
28.5
通讯作者：
Dhayat SA
中科院分区：
文献类型：
--
作者：
Reese M;Dhayat SA
胰腺癌是常见肿瘤中预后最差的一种，这与其侵袭性表型、晚期诊断、无法手术以及对系统治疗的抗拒有关。非编码RNAs(NcRNAs)，如microRNAs、长非编码RNAs和环状RNAs，已被确定为基因表达的重要调节因子，它们的解除调控与多种疾病，尤其是癌症有关。在肿瘤微环境中，非编码RNA可以通过细胞外小泡分布在癌细胞、间质细胞和免疫细胞之间，从而促进细胞间的沟通，影响主要的肿瘤标志，如血管生成、免疫系统逃避和转移扩散。此外，SEV-ncRNA作为液体活检具有诊断和预后意义。在这篇综述中，我们综述了SEV作为ncRNAs载体的作用以及在胰腺癌中潜在的分子机制。此外，我们回顾了SEV-ncRNAs作为生物标志物的潜力，并强调了SEV作为基于ncRNA的癌症治疗的递送载体的适用性。
Pancreatic cancer has the worst prognosis among common tumors which is attributed to its aggressive phenotype, diagnosis at advanced, inoperable stages, and resistance to systemic therapy. Non-coding RNAs (ncRNAs) such as microRNAs, long non-coding RNAs, and circular RNAs have been established as important regulators of gene expression and their deregulation has been implicated in multiple diseases and foremost cancer. In the tumor microenvironment, non-coding RNAs can be distributed among cancer cells, stromal cells, and immune cells via small extracellular vesicles (sEVs), thereby facilitating intercellular communication and influencing major cancer hallmarks such as angiogenesis, evasion of the immune system, and metastatic dissemination. Furthermore, sEV-ncRNAs have shown promising potential as liquid biopsies with diagnostic and prognostic significance. In this review, we summarize the role of sEVs as carriers of ncRNAs and underlying molecular mechanisms in pancreatic cancer. Moreover, we review the potential of sEV-ncRNAs as biomarkers and highlight the suitability of sEVs as delivery vehicles for ncRNA-based cancer therapy.
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DOI：
10.1158/1078-0432.ccr-11-1185
发表时间：
2011-09-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Carbone C;Moccia T;Zhu C;Paradiso G;Budillon A;Chiao PJ;Abbruzzese JL;Melisi D
通讯作者：
Melisi D
影响因子：
12.4
作者：
Bellavia D;Raimondo S;Calabrese G;Forte S;Cristaldi M;Patinella A;Memeo L;Manno M;Raccosta S;Diana P;Cirrincione G;Giavaresi G;Monteleone F;Fontana S;De Leo G;Alessandro R
通讯作者：
Alessandro R
DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Anastasiadou E;Jacob LS;Slack FJ
通讯作者：
Slack FJ
影响因子：
64.8
作者：
Chendrimada, TP;Gregory, RI;Shiekhattar, R
通讯作者：
Shiekhattar, R
影响因子：
4.3
作者：
Chen, Yue;Sun, Xian-Jun;Mao, Ai-Wu
通讯作者：
Mao, Ai-Wu