Molecular rhythms in the pineal gland.
Molecular rhythms in the pineal gland.
复制标题
松果体中的分子节律。
DOI：
10.1016/s0959-4388(98)80094-9
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发表时间：
1998
影响因子：
5.7
通讯作者：
Snyder,SH
中科院分区：
文献类型：
--
作者：
Li,X;Borjigin,J;Snyder,SH
最近的研究结果已经澄清了机制，调节夜间和松果体特异性转录的5-羟色胺N-乙酰转移酶，在褪黑激素的形成限速酶。去甲肾上腺素在夜间通过β-肾上腺素受体和cAMP起作用，刺激cAMP反应元件结合蛋白，其开启N-乙酰转移酶和诱导型cAMP早期阻遏物的转录，所述诱导型cAMP早期阻遏物是N-乙酰转移酶转录的主要抑制剂。松果体和视网膜内的组织特异性基因表达部分来自松果体/视网膜特异性转录因子，视锥-视杆同源框蛋白，其结合到松果体调节元件。这种调节元件存在于松果体选择性酶的启动子中，如N-乙酰转移酶、羟吲哚-O-甲基转移酶和松果体夜间特异性ATP酶
Recent findings have clarified the mechanisms regulating the night- and pineal-specific transcription of serotonin N-acetyltransferase, the rate-limiting enzyme in melatonin formation. Norepinephrine, acting via β-adrenoceptors and cAMP at night, stimulates the cAMP response element binding protein, which turns on the transcription of N-acetyltransferase and inducible cAMP early repressor, the major inhibitor of N-acetyltransferase transcription. The tissue-specific gene expression within the pineal gland and retinaderives, in part, from a pineal/retina-specific transcription factor, cone—rod homeobox protein, which binds to a pineal regulatory element. This regulatory element is present in promoters of pineal-selective enzymes, such as N-acetyltransferase, hydroxyindole-O-methyl transferase, and pineal night-specific ATPase