Fluorescence guided photothermal/photodynamic ablation of tumours using pH-responsive chlorin e6-conjugated gold nanorods
Fluorescence guided photothermal/photodynamic ablation of tumours using pH-responsive chlorin e6-conjugated gold nanorods
复制标题
使用 pH 响应型二氢卟酚 e6 共轭金纳米棒进行荧光引导的肿瘤光热/光动力消融
DOI：
10.1016/j.colsurfb.2017.09.045
复制
发表时间：
2017-12-01
影响因子：
5.8
通讯作者：
Hu, Yong
中科院分区：
文献类型：
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作者：
Zhang, Chao;Cheng, Xiao;Hu, Yong
光热/光动力疗法（PTT/PDT）已被广泛接受为消除肿瘤的非侵入性治疗方式。然而，这两种疗法都面临着精确定位肿瘤和减少其副作用的问题。二氢卟酚e6共轭金纳米棒（Ce 6-PEG-AuNR）是一种金纳米棒-光敏剂共轭物，被设计为一种纳米治疗剂，可同时实现PTT/PDT联合治疗。与游离Ce 6相比，Ce 6-PEG-AuNR中的纵向表面等离子体共振（LSPR）有效地猝灭了粘附在缀合物上的Ce 6的荧光。然而，当Ce 6与缀合物分离时，由于肿瘤组织中细胞内酸性条件导致Ce 6与PEG之间的腙键断裂，Ce 6的特异性荧光可以在肿瘤组织中恢复。基于这种效应，我们可以通过PTT/PDT组合精确定位肿瘤并进一步杀死癌细胞。此外，联合治疗（PTT/PDT）功能在癌症治疗中比PIT或PDT单独治疗更有效。因此，Ce 6-PEG-AuNR可以作为一种有前途的双模式光治疗剂以及肿瘤敏感的荧光探针来诊断和治疗癌症。(C)2017爱思唯尔B. V.保留所有权利。
Photothermal/photodynamic therapies (PTT/PDT) have been widely accepted as non-invasive therapeutic modalities to erase tumours. However, both therapies face the problem of precisely locating tumours and reducing their side effects. Herein, chlorin e6 conjugated gold nanorod, (Ce6-PEG-AuNR), a type of gold nanorod-photosensitizer conjugate, is designed as a kind of nano-therapeutic agent to simultaneously realize combined PTT/PDT. Compared to free Ce6, the fluorescence of Ce6 adhered to the conjugate is effectively quenched by the longitudinal surface plasmon resonance (LSPR) of in the Ce6-PEG-AuNR. However, the specific fluorescence of Ce6 can be recovered in tumour tissue when Ce6 is separated from the conjugate owing to the cleavage of hydrazone bond between Ce6 and PEG caused by intracellular acidic conditions in tumour tissue. Based on this effect, we can precisely locate tumours and further kill cancer cells by combined PTT/PDT. In addition, the combined therapy (PTT/PDT) function is more efficient in cancer treatment than that of PIT or PDT alone. Therefore, Ce6-PEG-AuNR can serve as a promising dual-modal phototherapeutic agent as well as a tumour-sensitive fluorescent probe to diagnose and treat cancer. (C) 2017 Elsevier B.V. All rights reserved.