The gene for retinal rod 33-kDa protein is on mouse chromosome 1, near Lamb2.
The gene for retinal rod 33-kDa protein is on mouse chromosome 1, near Lamb2.
复制标题
视网膜杆 33-kDa 蛋白的基因位于小鼠 1 号染色体上，靠近 Lamb2。
DOI：
10.1159/000133089
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Farber,DB
中科院分区：
文献类型：
--
作者：
Danciger,M;Kozak,CA;Abe,T;Shinohara,T;Farber,DB
一种具有光依赖性磷酸化的水溶性蛋白（称为“33-kDa蛋白”）已被证明是哺乳动物杆状光感受器的主要蛋白。虽然该蛋白的功能尚不清楚，但它与介导杆视觉反应的生化级联反应有关。利用来自大鼠和体细胞杂交体的视网膜cDNA，我们将与该蛋白对应的基因定位到小鼠1号染色体上，并通过分析亚种间回交的后代，将其定位在lamb2（层粘连蛋白的β2链）附近。我们将其命名为geneRpr-1（杆状光受体蛋白-1）。
A water-soluble protein (called “33-kDa protein”) that exhibits light-dependent phosphorylation has been shown to be a major protein of mammalian rod photoreceptors. Although the function of this protein is unknown, it has been implicated in the biochemical cascade mediating the rod visual response. Using a retinal cDNA from the rat and somatic cell hybrids, we have mapped the gene corresponding to this protein to mouse Chromosome 1 and, by analyzing the progeny of an intersubspecific backcross, have positioned it nearLamb2(the β2 chain of laminin). We have designated the geneRpr-1(rod photoreceptor protein-1).