Co-abrogation of Chk1 and Chk2 by potent oncolytic adenovirus potentiates the antitumor efficacy of cisplatin or irradiation
Co-abrogation of Chk1 and Chk2 by potent oncolytic adenovirus potentiates the antitumor efficacy of cisplatin or irradiation
复制标题
强效溶瘤腺病毒共同消除 Chk1 和 Chk2 可增强顺铂或放射的抗肿瘤功效
DOI:
10.1038/cgt.2014.20
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发表时间:
2014-05
影响因子:
6.4
通讯作者:
Gao, Q.
中科院分区:
文献类型:
--
作者:
Xi, B.;Zhou, J.;Ma, D.;Gao, Q.
Mammalian checkpoint kinases 1 and 2 (Chk1 and Chk2) are essential kinases that are involved in cell cycle checkpoint control, and the abrogation of either has been proposed as one way to sensitize cancer cells to DNA-damaging agents. However, it remains
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