STIMULATION OF CARTILAGE ZONES OF THE CALF COSTOCHONDRAL GROWTH PLATE INVITRO BY GROWTH-HORMONE DEPENDENT RAT PLASMA SOMATOMEDIN ACTIVITY
STIMULATION OF CARTILAGE ZONES OF THE CALF COSTOCHONDRAL GROWTH PLATE INVITRO BY GROWTH-HORMONE DEPENDENT RAT PLASMA SOMATOMEDIN ACTIVITY
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DOI：
10.1677/joe.0.0830219
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发表时间：
1979-01-01
影响因子：
4
通讯作者：
HILL, DJ
中科院分区：
文献类型：
--
作者：
HILL, DJ
体外研究了生长激素（GH）依赖性大鼠血浆生长激素（somatomedin）活性对犊牛肋软骨连接处软骨分离带的影响。血浆生长抑素最大限度地刺激了[3H]胸腺嘧啶进入增殖区软骨细胞的摄取。生长板较深处的软骨对[35S]硫酸盐的摄取最高，这也受到生长激素的刺激。Somatomedin似乎促进了整个生长板软骨的细胞复制和基质合成，尽管这两个过程在不同的软骨区域最大。生长激素或三碘甲状腺原氨酸没有直接改变两种同位素进入生长板软骨的摄取。
The actions of rat plasma somatomedin activity dependent on growth hormone [GH] were investigated in vitro on separated zones of cartilage from the calf costochondral junction. Plasma somatomedin maximally stimulated the uptake of [3H]thymidine into cartilage cells of the proliferating region. Cartilage deeper in the growth plate possessed the highest uptake of [35S]sulfate which was also stimulated by somatomedin. Somatomedin appears to promote both cell replication and matrix synthesis throughout the growth plate cartilage although the 2 processes were greatest in different cartilage regions. GH hormone or triodothyronine did not directly alter the uptake of either isotope into the growth plate cartilage.