The statistical basis of meta-analysis.
The statistical basis of meta-analysis.
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DOI：
10.1177/096228029300200202
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发表时间：
1993-01-01
影响因子：
2.3
通讯作者：
Fleiss, J L
中科院分区：
文献类型：
--
作者：
Fleiss, J L
在荟萃分析中提出了两个研究间变异的模型，并对其进行了评论和说明。一种是固定效应模型，将被分析的研究视为感兴趣的宇宙；另一种是随机效应模型，将这些研究视为从更大的可能研究群体中提取的样本。本文以临床试验为重点，较详细地说明了这两种模型在实验干预与对照效果的三个总结性度量中的应用：比较两个均值的标准化差，以及比较两个比例的相对风险和优势比。
Two models for study-to-study variation in a meta-analysis are presented, critiqued and illustrated. One, the fixed effects model, takes the studies being analysed as the universe of interest; the other, the random effects model, takes these studies as representing a sample from a larger population of possible studies. With emphasis on clinical trials, this paper illustrates in some detail the application of both models to three summary measures of the effect of an experimental intervention versus a control: the standardized difference for comparing two means, and the relative risk and odds ratio for comparing two proportions.