Sedating effects of ethanol and time of drinking.
Sedating effects of ethanol and time of drinking.
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乙醇的镇静作用和饮酒时间。
DOI：
10.1111/j.1530-0277.1992.tb01416.x
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Roth,T
中科院分区：
文献类型：
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作者：
Roehrs,T;Zwyghuizen-Doorenbos,A;Knox,M;Moskowitz,H;Roth,T
研究人员在一天中的两个不同时间（0900 点和 1700 点）对 12 名年龄在 21 岁至 45 岁之间、睡眠正常的健康男性注射乙醇（0.5 g/kg）。多次睡眠潜伏期测试 (MSLT) 在白天饮酒条件下的 1000、1200、1400 和 1600 小时以及晚上饮酒条件下的 1800、2000、2200 和 2400 小时进行。在安慰剂组中，白天测试时的睡意比晚上更强烈，这复制了睡意/警觉性昼夜节律的发现。有一个通过乙醇相互作用饮酒的时间（白天与晚上）。在白天，当警觉性相对较低时，乙醇对睡眠潜伏期有影响。晚上当警觉性水平提高时，乙醇未能对睡眠潜伏期产生显着影响。饮酒后 1 小时进行的分散注意力任务的表现因乙醇消耗而受到损害，但不随饮酒时间（白天与晚上）而变化。然而，在饮酒后 5 小时，乙醇在 40 分钟听觉警戒任务的前 20 分钟的平均反应时间在白天饮酒后比晚上饮酒后更大程度上减慢。
Ethanol (0.5 g/kg) was administered to 12 healthy, normal‐sleeping men, aged 21 to 45, at two different times of the day (0900 and 1700 hr). The Multiple Sleep Latency Test (MSLT) was conducted at 1000, 1200, 1400, and 1600 hr in the day drinking condition and at 1800, 2000, 2200, and 2400 hr in the evening drinking condition. On placebo, sleepiness was greater in the daytime testing hours than in the evening, replicating findings on the circadian rhythm of sleepiness/alertness. There was a time of drinking (day versus evening) by ethanol interaction. An ethanol effect on sleep latency was found in the daytime hours, when alertness was relatively low. Ethanol failed to have a significant effect on sleep latency during the evening hours when alertness levels were increasing. Performance on a divided attention task, administered 1 hr postconsumption, was impaired by ethanol consumption, but did not vary as a function of time of drinking (day versus evening). However, at 5 hr postconsumption, mean reaction time on the first 20 min of a 40‐min auditory vigilance task was slowed by ethanol to a greater extent after day drinking then after evening drinking.