The clinical utility of pharmacological agents that act at serotonin receptors.
The clinical utility of pharmacological agents that act at serotonin receptors.
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作用于血清素受体的药物的临床用途。
DOI：
10.1176/jnp.1.3.253
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Hekmatpanah,CR
中科院分区：
文献类型：
--
作者：
Peroutka,SJ;Sleight,AJ;McCarthy,BG;Pierce,PA;Schmidt,AW;Hekmatpanah,CR
在过去的十年中，在肾上腺素能药物的临床应用方面取得了重要进展。5-HT 1A部分激动剂（如丁螺环酮）的推定新型抗焦虑作用、选择性5-HT（5-HT）摄取阻断剂（如氟西汀）的抗抑郁作用以及5-HT 3拮抗剂在癌症化疗中的独特且有效的止吐作用是选择性5-HT受体药物临床相关性的极好实例。通过不同的5-HT受体亚型调节多巴胺能神经传递的能力的增加，将极大地促进正常和异常人脑功能中5-HT的分析。
The past decade has seen important advances in the clinical utility of serotonergic agents. The putative novel anxiolytic effects of 5-HT1A partial agonists such as buspirone, the antidepressant effects of selective serotonin (5-HT) uptake blockers such as fluoxetine, and the unique and potent antiemetic effects of 5-HT3 antagonists in cancer chemotherapy are excellent examples of the clinical relevance of selective 5-HT receptor agents. The increasing ability to modulate serotonergic neurotransmission through distinct 5-HT receptor subtypes should greatly facilitate the analysis of 5-HT in both normal and abnormal human brain function.