Synergistic Catalysis: A Powerful Synthetic Strategy for New Reaction Development.
Synergistic Catalysis: A Powerful Synthetic Strategy for New Reaction Development.
复制标题
DOI：
10.1039/c2sc00907b
复制
发表时间：
2012-01-01
期刊：
影响因子：
8.4
通讯作者：
Macmillan DW
中科院分区：
文献类型：
--
作者：
Allen AE;Macmillan DW
协同催化是一种合成策略，其中亲核剂和亲核剂同时被两个不同的催化剂激活，以提供单一的化学转化。这一强大的催化策略带来了几个好处，特别是协同催化可以(I)引入以前无法实现的新的化学转化，(Ii)提高现有转化的效率，以及(Iii)在以前没有立体控制或具有挑战性的地方创造或改善催化对映体选择性。这一观点旨在利用文献中发现的许多协同催化的成功例子来强调这些好处。
Synergistic catalysis is a synthetic strategy wherein both the nucleophile and the electrophile are simultaneously activated by two separate and distinct catalysts to afford a single chemical transformation. This powerful catalysis strategy leads to several benefits, specifically synergistic catalysis can (i) introduce new, previously unattainable chemical transformations, (ii) improve the efficiency of existing transformations, and (iii) create or improve catalytic enantioselectivity where stereocontrol was previously absent or challenging. This perspective aims to highlight these benefits using many of the successful examples of synergistic catalysis found in the literature.