FORMULATION OF TISSUE CONDITIONERS
FORMULATION OF TISSUE CONDITIONERS
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DOI：
10.1016/0142-9612(90)90082-2
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发表时间：
1990-10-01
期刊：
影响因子：
14
通讯作者：
BRADEN, M
中科院分区：
文献类型：
--
作者：
PARKER, S;BRADEN, M
牙科组织调节剂是一种顺应性凝胶，由聚合物粉末和增塑剂系统在义齿下原位形成。到目前为止，粉末一直是聚甲基丙烯酸乙酯，液体是邻苯二甲酸酯/乙醇混合物。这些材料是暂时的，因为它们在增塑剂淋洗后变硬。目前的工作旨在生产具有更长口腔寿命的材料。研究了一系列甲基丙烯酸正丁酯/甲基丙烯酸乙酯共聚物以及不同的酯-乙醇液体体系，考察了它们与各种醇和酯的凝胶化行为、凝胶体的粘弹性行为以及水的提取。以聚甲基丙烯酸乙酯为基础的材料表明，凝胶化速度取决于颗粒大小、粉末的球磨度和增塑剂的摩尔体积。基于甲基丙烯酸正丁酯/甲基丙烯酸乙酯共聚物的体系在液体体系中需要较少的乙醇或不需要乙醇，尽管凝胶速度非常依赖于温度。这些材料制成的凝胶具有更高的顺应性，在水介质中的顺应性比以聚甲基丙烯酸乙酯为基础的凝胶保持更长时间。
Dental tissue conditioners are compliant gels, formed in situ under a denture from a polymer powder and a plasticizer system. Hitherto, the powder has been poly(ethyl methacrylate) and the liquid a phthalate/ethanol mixture. These materials are temporary, because they harden from plasticizer leaching. The current work has been aimed at producing material with extended oral lifetimes. A range of n-butyl/ethyl methacrylate copolymers have been studied, together with various ester-ethanol liquid systems, with respect to gelation behavior with various alcohols and esters, viscoelastic behaviour of the set gels, and water extraction. Materials based on poly(ethyl methacrylate) show that gelation speed depends upon particle size, and the degree of ball milling of the powder, and the molar volume of the plasticizer. Systems based on n-butyl/ethyl methacrylate copolymers need less or no ethanol in the liquid system, although gelation speed is very temperature dependent. The gels from these last materials are more compliant, and retain their compliance longer in aqueous media than those based on poly(ethyl methacrylate).