Scandium-catalyzed highly selective N-2-alkylation of benzotriazoles with cyclohexanones
Scandium-catalyzed highly selective N-2-alkylation of benzotriazoles with cyclohexanones
复制标题
钪催化苯并三唑与环己酮的高选择性 N-2-烷基化
DOI：
10.1039/d0qo01060j
复制
发表时间：
2021
影响因子：
5.4
通讯作者：
Sun Jiangtao
中科院分区：
文献类型：
--
作者：
Tang Shengbiao;Yu Jianliang;Shao Ying;Sun Jiangtao
本文报道了一种钪催化的苯并三唑与环己酮的高N2选择性烷基化反应，以高产率和优异的区域选择性直接合成了一系列具有新的四取代碳中心的N2烷基化苯并三唑。该反应成功的关键是使用Sc（OTf）3作为催化剂。通常，该方案也与4-芳基-1，2，3-三唑很好地相容。
A scandium-catalyzed highly N2-selective alkylation of benzotriazoles with cyclohexanones has been developed, providing straightforward access to a series of N2-alkylated benzotriazoles featuring newly formed tetrasubstituted carbon centers in high yields with excellent regioselectivities. The key to the success of this reaction is using Sc(OTf)3 as the catalyst. Typically, this protocol is also well compatible with 4-aryl-1,2,3-triazoles.