Methadone versus morphine for treatment of neonatal abstinence syndrome: A prospective randomized clinical trial
Methadone versus morphine for treatment of neonatal abstinence syndrome: A prospective randomized clinical trial
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DOI：
10.1038/jp.2014.194
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发表时间：
2015-04-01
影响因子：
2.9
通讯作者：
Thornton, L. M.
中科院分区：
文献类型：
--
作者：
Brown, M. S.;Hayes, M. J.;Thornton, L. M.
目的：比较美沙酮和吗啡治疗新生儿戒断综合征的持续时间。研究设计：一项前瞻性、双盲、随机试验。美沙酮或吗啡的随机化按美沙酮或丁丙诺啡的母体治疗分层。入选标准为（i）母亲接受处方美沙酮或丁丙诺啡治疗，（ii）停药治疗标准，（iii）校正胎龄>= 35（0/7）周和（iv）医学稳定。结果：从2011年1月到2012年10月，78名婴儿有资格参加这项研究：41名美沙酮暴露和37名丁丙诺啡暴露。获得了31位母亲的同意，13/41（32%）接受美沙酮治疗，18/37（49%）接受丁丙诺啡治疗。美沙酮的阿片类药物治疗时间明显短于吗啡治疗，中位数为14天与21天（P = 0.008）。结论：美沙酮的新生儿戒断治疗时间较短，吗啡。由于样本量较小和单中心，需要进行更大规模的随机研究。
OBJECTIVE: Compare duration of treatment of neonatal abstinence syndrome between methadone and morphine.STUDY DESIGN: A prospective, double-masked, randomized trial at a single site. Randomization of methadone or morphine was stratified for maternal treatment with methadone or buprenorphine. Inclusion criteria were (i) maternal treatment with prescribed methadone or buprenorphine, (ii) withdrawal treatment criteria, (iii) adjusted gestational age >= 35(0/7) weeks and (iv) medically stable. Primary outcome was length of opioid treatment.RESULT: From January 2011 through October 2012, 78 infants were eligible for the study: 41 methadone-exposed and 37 buprenorphine-exposed. Consent was obtained from 31 mothers, 13/41 (32%) methadone-treated and 18/37 (49%) buprenorphine-treated. Length of opioid treatment was significantly shorter for methadone than morphine treatment, median 14 versus 21 days (P = 0.008).CONCLUSION: Methadone had a shorter length of neonatal withdrawal treatment compared with morphine. Owing to the smaller sample size and single site, a larger randomized study is needed.