Circulating 25-hydroxyvitamin D, nasopharyngeal microbiota, and bronchiolitis severity.
Circulating 25-hydroxyvitamin D, nasopharyngeal microbiota, and bronchiolitis severity.
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循环 25-羟基维生素 D、鼻咽微生物群和细支气管炎严重程度。
DOI：
10.1111/pai.12977
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
CamargoJr,CarlosA
中科院分区：
文献类型：
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作者：
Toivonen,Laura;Hasegawa,Kohei;Ajami,NadimJ;Celedón,JuanC;Mansbach,JonathanM;Petrosino,JosephF;CamargoJr,CarlosA
细支气管炎是美国婴儿住院的主要原因，其中约 15% 需要重症监护。 1 新证据表明，在细支气管炎的病理学中，病毒感染、气道微生物群和宿主免疫反应之间存在复杂的相互作用。 2 维生素 D 化合物对先天性和适应性免疫反应具有多效性调节作用。 3 维生素 D 的主要循环形式 25-羟基维生素 D (25OHD) 水平低，已被发现与儿童急性呼吸道感染 (ARIs) 的较高风险和严重程度相关。 4 最近的研究还报告了母体 5 和脐带血 6 维生素 D 水平与婴儿肠道微生物群之间的关联。然而，尚无研究调查循环 25OHD 和气道微生物群之间的相互作用对儿童 ARI 严重程度的影响。我们之前曾报道过，鼻咽部微生物群以嗜血杆菌为主的婴儿在细支气管炎住院期间接受重症监护的风险最高。 1 在当前的分析中，我们检查了相同的
Bronchiolitis is the leading cause of hospitalization in US infants, among which approximately 15% require intensive care. 1 Emerging evidence suggest a complex interplay between viral infection, airway microbiota, and host immune response in the pathobiology of bronchiolitis. 2 Vitamin D compounds have pleiotropic regulatory roles on both innate and adaptive immune responses. 3 Low levels of 25-hydroxyvitamin D (25OHD), the major circulating form of vitamin D, have been found to be associated with higher risk and severity of acute respiratory infections (ARIs) in children. 4 Recent studies also have reported an association of maternal5 and cord blood6 vitamin D levels with infant gut microbiota. Yet, there have been no studies investigating interactions between circulating 25OHD and airway microbiota on ARI severity in children. We have previously reported that infants with Haemophilus-dominant nasopharyngeal microbiota profile are at highest risk for intensive care use during bronchiolitis hospitalization. 1 In the current analysis, we examined the same