Stereological quantitation in cerebella from people with schizophrenia
Stereological quantitation in cerebella from people with schizophrenia
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DOI：
10.1192/bjp.182.4.354
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发表时间：
2003-04-01
影响因子：
10.5
通讯作者：
Pakkenberg, B
中科院分区：
文献类型：
--
作者：
Andersen, BB;Pakkenberg, B
精神分裂症的行为学和解剖学研究表明小脑受累。目的为提供精神分裂症患者和对照组使用死后材料的小脑体积和细胞数量的体视学估计。方法体视学方法应用于8例男性患者的小脑，诊断为DSM - III慢性精神分裂症，无神经系统疾病。（平均年龄575岁）和10名男性对照（平均年龄56.2岁）。Cavalieri原则被用来提供估计的体积，光学disector方法，以获得估计的浦肯野细胞和颗粒细胞的数量密度，并结合两者，以获得估计的小脑中的细胞总数。结果精神分裂症患者小脑主要体积、细胞数量及浦肯野细胞体积均无明显差异。结论精神分裂症患者小脑最常见的病理改变是小脑蚓部萎缩，小脑小脑皮质萎缩是小脑皮质的主要病理改变，小脑皮质萎缩是小脑皮质的主要病理改变，小脑皮质萎缩是小脑皮质的主要病理改变。在这一小群严重受影响的患者中没有发现。利益声明这项工作得到了哈特曼兄弟基金会的支持，斯坦利基金会和I. M. K. Almene基金。
Background Behavioural and anatomical studies in schizophrenia have pointed to cerebellar involvement.Aims To provide stereological estimations of volumes and cell number in the cerebella of people with schizophrenia and a control group using post-mortem material.Method Stereological methods were applied to cerebella taken from eight male patients with a DSM - III diagnosis of chronic schizophrenia with no neurological disorder (mean age 575 years) and ten male controls (mean age 56.2 years). The-Cavalieri principle was used to provide estimates of volumes, the optical disector method to obtain estimates of the numerical density of Purkinje and granule cells, and a combination of the two to obtain estimates of total cell numbers in the cerebellum. The rotator method-was applied to obtain estimates of mean Purkinje cell volume.Results No global structural difference in major volumes, cell numbers or Purkinje cell volume was found between the groups.Conclusions The most frequently reported pathological finding in the cerebellum in schizophrenia is vermal atrophy, which was not found in this small group of heavily affected patients.Declaration of interest This work was supported by the Hartmann Brothers Foundation, the Stanley Foundation and the I. M. K. Almene Fund.