The role of irradiation in central nervous system treatment and prophylaxis for acute lymphoblastic leukemia
The role of irradiation in central nervous system treatment and prophylaxis for acute lymphoblastic leukemia
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照射在中枢神经系统治疗和预防急性淋巴细胞白血病中的作用
作者：
A. Dritschilo;J. Cassady;B. Camitta;N. Jaffe;L. Furman;D. Traggis
本文介绍了在联合放射治疗中心、儿童医院医学中心和悉尼法伯癌症中心对117例ALL儿童进行颅脑照射和鞘内甲氨蝶呤治疗的中枢神经系统（CNS）结果。与预后相关的脑膜疾病的分类，并在这些组内的患者进行分析。在80例被归类为最有利组（I和II）的患者中，没有儿童发生原发性CNS复发。在不太有利的组（III、IV和V）中的其余37名患者中，8名患者经历了CNS复发，5名在骨髓复发之后或与骨髓复发一起。辐射的技术特点进行了审查，并与治疗的成功。
The results of central nervous system (CNS) treatment with craniocervical irradiation and intrathecal methotrexate in 117 children with ALL achieved at the Joint Center for Radiation Therapy, The Children's Hospital Medical Center, and The Sidney Farber Cancer Center are presented. A classification related to meningeal disease which correlates with prognosis is presented and the patients are analyzed within these groups. Of 80 patients classified in the most favorable groups (I and II), no child has suffered primary CNS relapse. Of the remaining 37 patients in less favorable groups (III, IV, and V), eight patients have experienced CNS relapse, five following or in conjunction with bone marrow relapse. The technical features of irradiation are reviewed and related to success of the treatment.