Both CD4+ T cells and CD8+ T cells are required for iodine accelerated thyroiditis in NOD mice
Both CD4+ T cells and CD8+ T cells are required for iodine accelerated thyroiditis in NOD mice
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DOI：
10.1006/cimm.1998.1446
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发表时间：
1999-03-15
影响因子：
4.3
通讯作者：
Cooke, A
中科院分区：
文献类型：
--
作者：
Hutchings, PR;Verma, S;Cooke, A
非肥胖糖尿病（NOD）小鼠是一种胰岛素依赖型糖尿病的自发动物模型，尽管甲状腺病变的发生率和严重程度在世界各地不同群体之间存在很大差异，但它与人类糖尿病群体表现出共同的发展自身免疫性甲状腺炎的趋势。最近衍生出一种在 NOD 背景上携带 I-Ak 的 NOD 小鼠同系品系 (NOD-H2(h4))，尽管它没有患糖尿病，但它表现出更大的患甲状腺炎和小鼠甲状腺球蛋白 (MTg) 自身抗体的倾向。通过增加碘摄入量，NOD-H2(h4) 小鼠的甲状腺浸润和自身抗体形成都会加速和增强。增加碘摄入量对 NOD 小鼠本身的影响尚未得到直接研究，尽管最近对这些动物给予高剂量或低剂量碘的研究显示，除非小鼠首先因缺碘而甲状腺肿大，否则卵泡不会受到破坏。我们发现，尽管不存在针对 MTg 的自身抗体，但饮食中的碘会增加 NOD 小鼠甲状腺病变的发生率和严重程度。 NOD 背景基因似乎对于这些病变的发展至关重要，在服用碘 4 周后达到最大，并且在停止碘时没有显示出显着的消退。此外，我们的研究首次表明，CD4(+) 和 CD8(+) T 细胞对于这种加速但本质上是自发的小鼠甲状腺疾病的发展是必需的。 (C) 1999 年学术出版社。
The nonobese diabetic (NOD) mouse, a spontaneous animal model for insulin-dependent diabetes mellitus, displays a tendency in common with human diabetic populations to develop autoimmune thyroiditis although incidence and severity of thyroid lesions vary widely among different colonies around the world. A congenic strain of NOD mice bearing I-Ak on a NOD background (NOD-H2(h4)) has recently been derived and displays a much greater tendency to develop thyroiditis and autoantibodies to mouse thyroglobulin (MTg) although it is free of diabetes. Both thyroid infiltrates and autoantibody formation are accelerated and enhanced in NOD-H2(h4) mice by increased iodine intake. The effect of increased iodine intake on NOD mice themselves has not been directly investigated although a recent study of these animals given high or low doses of iodine showed no follicular destruction unless the mice were first rendered goitrous by iodine deprivation. We found that dietary iodine increased both the incidence and the severity of thyroid lesions in our NOD mice although autoantibodies to MTg were absent. NOD background genes appear to be essential for the development of these lesions, which were maximal after 4 weeks of iodine administration and showed no significant regression when the iodine was stopped. Furthermore, our studies show for the first time that both CD4(+) and CD8(+) T cells are necessary for the development of this accelerated but essentially spontaneous murine thyroid disease. (C) 1999 Academic Press.