Frequency Distribution of Esterase-5 Alleles in Two Populations of DROSOPHILA PSEUDOOBSCURA.
Frequency Distribution of Esterase-5 Alleles in Two Populations of DROSOPHILA PSEUDOOBSCURA.
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两个果蝇种群中 Esterase-5 等位基因的频率分布。
DOI：
10.1093/genetics/105.1.135
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发表时间：
1983
期刊：
影响因子：
3.3
通讯作者：
T. Keith
中科院分区：
文献类型：
--
作者：
T. Keith
将自然群体中的等位基因频率与各种基因变异理论预测的等位基因频率进行比较的统计检验，关键取决于等位基因的准确计数。本研究采用一系列五种连续的电泳条件，研究了来自加州的两个大种群样本中酯酶-5的等位基因频率分布。在标准染色体系中，用一个单一的电泳条件区分了12个电泳体。当使用四个额外的标准时，电针的数量增加到41个，一个种群中有33个，另一个种群中有22个。两个群体具有相同的两个等位基因，频率较高，其他等位基因的频率不超过6%。虽然每个群体都有一些独特的等位基因，但X(2)权变检验表明它们之间没有显著的遗传差异。两个群体的等位基因频率与中性模型预测的等位基因频率的统计比较表明，个体和组合分布在纯化选择的方向上偏离了中性。-性别比染色体在等位基因含量和多样性方面与标准染色体都有显著差异。在一个群体的32条性比染色体中，只发现了3个等位基因，这些等位基因都是在最初的“标准”电泳条件下检测到的。此外，这些等位基因在标准染色体系中均未发现。
Statistical tests comparing allele frequencies in natural populations with those predicted by various theories of genic variation depend critically on the accurate enumeration of alleles. This study used a series of five sequential electrophoretic conditions to characterize the allele frequency distributions of esterase-5 in two large population samples of Drosophila pseudoobscura from California. In Standard chromosome lines 12 electromorphs were discriminated using a single electrophoretic condition. When four additional criteria were used, the number of electromorphs increased to 41, 33 in one population and 22 in the other. Both populations had the same two alleles in high frequency, with other alleles present in frequencies of 6% or less. Although each population had a number of unique alleles, a chi(2) contingency test demonstrated no significant genetic divergence between them. A statistical comparison of allele frequencies in both populations with that predicted by neutral models suggests that the individual and combined distributions deviate from neutrality in the direction of purifying selection.-Sex-Ratio chromosomes differed markedly from Standard chromosomes in both allelic content and diversity. In 32 Sex-Ratio chromosomes from one population only three alleles were found, all of which were detected under the initial "standard" electrophoretic conditions. Moreover, none of these alleles was found in the Standard chromosome lines.
果蝇的基因流和分子多态性的地理分布。
影响因子：
3.3
作者：
Jones,JS;Bryant,SH;Lewontin,RC;Moore,JA;Prout,T
通讯作者：
Prout,T