Early symptoms of mania and the role of parental risk
Early symptoms of mania and the role of parental risk
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DOI：
10.1111/j.1399-5618.2005.00260.x
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发表时间：
2005-12-01
影响因子：
5.4
通讯作者：
Calabrese, JR
中科院分区：
文献类型：
--
作者：
Findling, RL;Youngstrom, EA;Calabrese, JR
目的：本研究的目的是：(I)描述被诊断为亚综合征双相情感障碍的青少年的现象学；(Ii)描述双相父母的孩子也有双相情感障碍亚综合征症状的青少年的现象学；以及(Iii)探索哪些症状最有助于识别青少年的睫状核趋向性。方法：400名5-17岁的门诊患者接受了关于情绪症状和心理社会功能的诊断评估和心理测量问卷。还获得了父母的诊断信息。儿童和青少年被分为三个诊断组之一：“综合征双相情感障碍”组(n=118)，“亚综合征双相情感障碍”组(n=75)，或“非双相双相情感障碍”组(n=207)。此外，根据父母的诊断，将年轻人分为高遗传风险组(n=167)和低遗传风险组(n=233)。结果：亚综合征双相情感障碍青年的躁狂症状比双相情感障碍青年和没有双相情感障碍的青年有中等程度的躁狂症状。与父母没有双相情感障碍的年轻人相比，患有双相情感障碍的父母的后代更有可能表现出轻躁和躁狂的症状。研究发现，患有双相情感障碍的遗传风险较高的年轻人患注意力缺陷多动障碍或破坏性行为障碍的风险较高。最后，研究结果表明，情绪高涨、易怒和情绪快速波动是睫状肌趋化症的主要特征。结论：存在一组父母/父母患有双相情感障碍的子女，他们没有患BP1或BP2，但情绪症状升高，心理社会功能障碍。作为这些观察的结果，需要对患有“睫状肌趋化”的年轻人进行治疗研究。
Objectives: The objectives of this study were to: (i) describe the phenomenology of youths diagnosed with subsyndromal bipolar disorders; (ii) describe the phenomenology of youngsters who are the children of bipolar parents, who are also experiencing subsyndromal symptoms of bipolar disorder (patients with 'cyclotaxia'); and (iii) explore which symptoms may be most useful in identifying youths with cyclotaxia.Methods: Four hundred outpatients between the ages of 5 and 17 years received a diagnostic assessment and psychometric questionnaires pertaining to mood symptomatology and psychosocial functioning. Parental diagnostic information was also obtained. Children and adolescents were assigned to one of three diagnostic groups: a 'syndromal bipolar disorder (BP)' group (n = 118), a 'sub-syndromal bipolar (SUB-BP)' group (n = 75), or a 'non-bipolar (NON-BP)' group (n = 207). In addition, based on parental diagnoses, youths were assigned to either a high genetic risk group (n = 167) or a low genetic risk group (n = 233).Results: Youths with subsyndromal bipolar disorders were found to have intermediate degrees of manic symptoms than youths with bipolar disorder and youths without a bipolar diagnosis. Offspring of parents having a bipolar disorder were more likely to show symptoms of hypomania and mania than youths without a bipolar parent. Youths at genetic risk for developing a bipolar disorder were not found to be at higher risk for having a diagnosis of attention-deficit hyperactivity disorder or a disruptive behavior disorder. Finally, results suggest that elevated mood with irritability and rapid mood fluctuations are the key distinguishing characteristics of 'cyclotaxia'.Conclusions: There exists a group of youngsters who are the offspring of a parent/parents with a bipolar disorder who do not suffer from BP 1 or BP 2, yet have elevated mood symptoms and psychosocial dysfunction. As a result of these observations, treatment studies are needed for youths with 'cyclotaxia'.