Thermosensitive magnetic nanoparticles exposed to alternating magnetic field and heat-mediated chemotherapy for an effective dual therapy in rat glioma model
Thermosensitive magnetic nanoparticles exposed to alternating magnetic field and heat-mediated chemotherapy for an effective dual therapy in rat glioma model
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DOI：
10.1016/j.nano.2020.102319
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发表时间：
2021-01-01
影响因子：
5.4
通讯作者：
Karimi, Mohammad Yahya
中科院分区：
文献类型：
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作者：
Afzalipour, Reza;Khoei, Samideh;Karimi, Mohammad Yahya
本研究的目的是开发一种基于肿瘤热疗的新方法，同时使用替莫唑胺（TMZ）负载的叶酸缀合磁性纳米颗粒（TMZ/MNPs-FA）和交变磁场（AMF），并评估其治疗大鼠C6胶质瘤的疗效。制备了TMZ/MNPs-FA，并对其尺寸、表面电荷、磁饱和度、溶血性和体外AMF触发释放进行了评价。在AMF存在或不存在的情况下（43 ℃），用游离TMZ、MNPs-FA和TMZ/MNPs-FA处理胶质瘤大鼠模型。结果表明，AFM热疗与温敏TMZ/ MNPs-FA联合治疗能显著抑制肿瘤生长，提高生存率，促进肿瘤细胞凋亡（P < 0.0001）。因此，这种治疗策略可能是治疗癌症的强大模式，因为暴露于AMF的磁性纳米颗粒的热和机械效应可以增加常规化疗的治疗效果。(c)2020爱思唯尔公司All rights reserved.
The goal of this study was to develop a new method based on Oncothermia with concomitant use of the temozolomide (TMZ)-loaded magnetic nanoparticles conjugated with folic acid (TMZ/MNPs-FA) and alternative magnetic field (AMF) and evaluate its efficacy in the treatment of C6 glioma in rats. TMZ/MNPs-FA were prepared and evaluated for their size, surface charge, magnetic saturation, hemolysis and in vitro AMF-triggered release. The glioma rat models were treated with free TMZ, MNPs-FA and TMZ/MNPs-FA in the presence or absence of AMF (43 degrees C). The results confirmed that a combinatorial therapy consisting of AFM hyperthermia and thermosensitive TMZ/ MNPs-FA could significantly suppress tumor growth, increase survival rate and promote apoptosis (P < 0.0001). Therefore, this treatment strategy may be a powerful modality for treatment of cancer, as the thermal and mechanical effects of magnetic nanoparticles exposed to AMF can increase the therapeutic efficacy of conventional chemotherapy. (c) 2020 Elsevier Inc. All rights reserved.