Use of dextran nanoparticle: A paradigm shift in bacterial exopolysaccharide based biomedical applications
Use of dextran nanoparticle: A paradigm shift in bacterial exopolysaccharide based biomedical applications
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DOI：
10.1016/j.ijbiomac.2016.02.059
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发表时间：
2016-06-01
影响因子：
8.2
通讯作者：
Bandopadhyay, Rajib
中科院分区：
文献类型：
--
作者：
Banerjee, Aparna;Bandopadhyay, Rajib
这篇综述是一个简洁的汇编所有主要的研究葡聚糖纳米粒子为基础的生物医学应用。右旋糖酐是一种具有简单重复葡萄糖亚基的高度生物相容性和可生物降解的中性细菌胞外多糖。它简单而独特的生物聚合物性质使其非常适合作为纳米医学，纳米药物载体，细胞成像系统或纳米生物传感器。最重要的是，它是极水溶性的，并且不显示药物递送后的细胞毒性。右旋糖酐在体内完全代谢是可能的，因此肾衰竭的可能性最小。基于葡聚糖的纳米颗粒具有上级的水溶性、高负载容量和特性粘度以及短的储存期。这次审查的主要重点领域是-过去和现在的主要生物医学应用的葡聚糖为基础的纳米材料，从而显示了细菌胞外多糖为基础的纳米生物技术的范式转变。(C)© 2016 Elsevier B. V.版权所有。
This review is a concise compilation of all the major researches on dextran nanoparticle based biomedical applications. Dextran is a highly biocompatible and biodegradable neutral bacterial exopolysaccharide with simple repeating glucose subunits. It's simple yet unique biopolymeric nature made it highly suitable as nanomedicine, nanodrug carrier, and cell imaging system or nanobiosensor. Most importantly, it is extremely water soluble and shows no post drug delivery cellular toxicity. Complete metabolism of dextran is possible inside body thus possibility of renal failure is minimum. Dextran based nanoparticles have superior aqueous solubility, high cargo capacity and intrinsic viscosity, and short storage period. The main focus area of this review is- past and present of major biomedical applications of dextran based nanomaterials thus showing a paradigm shift in bacterial exopolysaccharide based nanobiotechnology. (C) 2016 Elsevier B.V. All rights reserved.