Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling
Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling
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DOI：
10.1016/s0962-8924(99)01612-8
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发表时间：
1999-08-01
影响因子：
19
通讯作者：
Hannigan, G
中科院分区：
文献类型：
--
作者：
Dedhar, S;Williams, B;Hannigan, G
细胞与细胞外基质（ECM）的相互作用导致通过整合素和生长因子受体的协调信号转导来调节细胞生长、分化和迁移。整合素通过与将整合素和生长因子受体偶联至下游组分的细胞内效应物相互作用来实现信号传导。一种研究充分的效应子是粘着斑激酶（FAK），但最近另一种蛋白激酶，整合素连接激酶（ILK）已被鉴定为整合素和生长因子信号传导的受体近端效应子。ILK似乎与许多不同的信号传导途径相互作用并受其影响，这为整合素介导的信号传导提供了新的途径。本文讨论了ILK的结构和功能，以及ILK在信号转导中的作用的最新遗传和生化证据。
Interaction of cells with the extracellular matrix (ECM) results in the regulation of cell growth, differentiation and migration by coordinated signal transduction through integrins and growth-factor receptors. Integrins achieve signalling by interacting with intracellular effecters that couple integrins and growth-factor receptors to downstream components. One well-studied effector is focal-adhesion kinase (FAK) but recently another protein kinase, integrin-linked kinase (ILK) has been identified as a receptor-proximal effector of integrin and growth-factor signalling. ILK appears to interact with and be influenced by a number of different signalling pathways, and this provides new routes for integrin-mediated signalling. This article discusses ILK structure and function and recent genetic and biochemical evidence about the role of ILK in signal transduction.