Transcriptional control of mitosis: deregulation and cancer.
Transcriptional control of mitosis: deregulation and cancer.
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DOI：
10.3389/fendo.2015.00060
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发表时间：
2015
影响因子：
5.2
通讯作者：
Roychoudhury S
中科院分区：
文献类型：
--
作者：
Nath S;Ghatak D;Das P;Roychoudhury S
过去几十年的研究已经充分确定了有丝分裂的分子功能。这些功能的失调也归因于不同肿瘤类型中非整倍体的产生。许多研究已经深入了解细胞周期特异性蛋白对有丝分裂的调控。这些蛋白质的最佳丰度对于有丝分裂的及时执行至关重要。这些有丝分裂蛋白的异常表达已在不同的癌症类型中报道。随后确定了控制有丝分裂蛋白水平的几种转录后机制及其相互作用。然而，迄今为止，很少有癌症相关突变的发生率已报告的基因表达这些蛋白质。因此，肿瘤样本中这些有丝分裂调节因子的表达改变在很大程度上归因于转录失调。本文综述了有丝分裂的转录控制生物学，并评估其在非整倍体和肿瘤发生中的作用。
Research over the past few decades has well established the molecular functioning of mitosis. Deregulation of these functions has also been attributed to the generation of aneuploidy in different tumor types. Numerous studies have given insight into the regulation of mitosis by cell cycle specific proteins. Optimum abundance of these proteins is pivotal to timely execution of mitosis. Aberrant expressions of these mitotic proteins have been reported in different cancer types. Several post-transcriptional mechanisms and their interplay have subsequently been identified that control the level of mitotic proteins. However, to date, infrequent incidences of cancer-associated mutations have been reported for the genes expressing these proteins. Therefore, altered expression of these mitotic regulators in tumor samples can largely be attributed to transcriptional deregulation. This review discusses the biology of transcriptional control for mitosis and evaluates its role in the generation of aneuploidy and tumorigenesis.
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影响因子：
37.3
作者：
Courapied S;Cherier J;Vigneron A;Troadec MB;Giraud S;Valo I;Prigent C;Gamelin E;Coqueret O;Barré B
通讯作者：
Barré B
DOI：
10.1038/nrc1299
发表时间：
2004-03
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.3
作者：
Bae, I;Rih, JK;Rosen, EM
通讯作者：
Rosen, EM
DOI：
10.1016/j.bbaexp.2007.07.005
发表时间：
2007-09-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
影响因子：
--
作者：
Cheng, Liansheng;Li, Liangwei;Yao, Xuebiao
通讯作者：
Yao, Xuebiao
影响因子：
4
作者：
Chi, Ya-Hui;Jeang, Kuan-Teh
通讯作者：
Jeang, Kuan-Teh