Thyroid hormones and protein synthesis in fetal mouse liver erythroid cells.
Thyroid hormones and protein synthesis in fetal mouse liver erythroid cells.
复制标题
胎鼠肝红细胞中的甲状腺激素和蛋白质合成。
作者：
J. Fuhr;C. D. Dunn
血红蛋白的合成是发育中的红细胞成熟的重要一步。在这项研究中，我们确定了各种甲状腺激素和类似物对珠蛋白合成的胎鼠肝红系细胞的影响。珠蛋白合成在13- 15天胎肝红系细胞中被刺激，而17天胎肝红系细胞则无反应。珠蛋白合成的刺激和报告的各种激素测定的产热活性之间没有相关性。
Hemoglobin synthesis represents an important step in the maturation of the developing erythron. In this study, we determined the effect of various thyroid hormones and analogs upon globin synthesis by fetal mouse liver erythroid cells. Globin synthesis was stimulated in 13--15 day fetal liver erythroid cells, whereas cells, whereas cells from 17 day fetuses were unresponsive. There was no correlation between stimulation of globin synthesis and reported calorigenic activity of the various hormones assayed.