Binding of Epidermal Growth Factor and Insulin‐Like Growth Factor I in Human Myometrium and Leiomyomata
Binding of Epidermal Growth Factor and Insulin‐Like Growth Factor I in Human Myometrium and Leiomyomata
复制标题
人子宫肌层和平滑肌瘤中表皮生长因子和胰岛素样生长因子 I 的结合
作者：
PÄIVI TOMMOLA;F. Pekonen;E. Rutanen
Samples of uterine myometrium and leiomyoma from 11 women were analyzed for the presence of epidermal growth factor receptors and insulin-like growth factor I receptors. In addition, the content of soluble insulin-like growth factor binding protein (IGF-BP/PP12) was measured in the tissue cytosols. Cell membrane preparations of myoma tissue bound significantly more insulin-like growth factor I than did those of adjacent normal myometrium, whereas myoma tissue bound less epidermal growth factor than did the normal myometrium. The differences in both insulin-like growth factor I and epidermal growth factor binding were due to changes in receptor concentration rather than to alterations hi receptor affinity. Neither myoma nor myometrial tissue contained detectable levels of insulin-like growth factor binding protein. The changes in epidermal growth factor and insulin-like growth factor I binding to the myometrium may play a role in the pathogenesis of uterine leiomyomata.
