Simultaneous PET-MRI reveals brain function in activated and resting state on metabolic, hemodynamic and multiple temporal scales
Simultaneous PET-MRI reveals brain function in activated and resting state on metabolic, hemodynamic and multiple temporal scales
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DOI：
10.1038/nm.3290
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发表时间：
2013-09-01
期刊：
影响因子：
82.9
通讯作者：
Pichler, Bernd J.
中科院分区：
文献类型：
--
作者：
Wehrl, Hans F.;Hossain, Mosaddek;Pichler, Bernd J.
正电子发射断层扫描（PET）和磁共振成像（MRI）相结合是研究大脑功能过程的新工具。在这里，我们同时使用 PET（在缓慢的时间尺度上追踪葡萄糖代谢的变化）和功能性 MRI (fMRI)（评估激活过程中快速的血管和氧合变化）研究大脑响应桶状场刺激的功能。我们发现 PET 和 fMRI 激活数据之间存在空间和定量差异。通过两种方式评估大鼠大脑的功能连接：fMRI 方法确定了总共九个已知的神经网络，而 PET 方法确定了七个葡萄糖代谢相关网络。这些结果证明了组合 PET-MRI 用于同时研究大脑激活和休息时的可行性，揭示全面和互补的信息，以进一步解码大脑功能和大脑网络。
Combined positron emission tomography (PET) and magnetic resonance imaging (MRI) is a new tool to study functional processes in the brain. Here we study brain function in response to a barrel-field stimulus simultaneously using PET, which traces changes in glucose metabolism on a slow time scale, and functional MRI (fMRI), which assesses fast vascular and oxygenation changes during activation. We found spatial and quantitative discrepancies between the PET and the fMRI activation data. The functional connectivity of the rat brain was assessed by both modalities: the fMRI approach determined a total of nine known neural networks, whereas the PET method identified seven glucose metabolism related networks. These results demonstrate the feasibility of combined PET-MRI for the simultaneous study of the brain at activation and rest, revealing comprehensive and complementary information to further decode brain function and brain networks.