BOLD-fMRI response vs. transcranial magnetic stimulation (TMS) pulse-train length: Testing for linearity
BOLD-fMRI response vs. transcranial magnetic stimulation (TMS) pulse-train length: Testing for linearity
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DOI：
10.1002/jmri.10271
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发表时间：
2003-03-01
影响因子：
4.4
通讯作者：
George, MS
中科院分区：
文献类型：
--
作者：
Bohning, DE;Shastri, A;George, MS
目的：测量运动和听觉皮质血氧水平依赖(BOLD)功能磁共振成像(FMRI)对脉冲样经颅磁刺激(TMS)脉冲的反应随列车长度的变化。材料和方法：在1.5T的fMRI的交错扫描下，以1 Hz的频率将0.3-ms的TMS脉冲施加于运动皮质区域，用于拇指。6名受试者在tr=1第二会话中管理1、2、4、8和16个脉冲的训练，并且在tr=3秒的会话中管理1、2、4、8、16和24个脉冲的训练。结果：无论是TMS对运动皮质的直接激活，还是TMS线圈引出的听觉皮质的间接激活，BOLD-fMRI对多个脉冲的反应都可以用单脉冲脉冲函数的总和来很好地描述。结论：在24个离散脉冲下，运动皮质和听觉皮质对1 Hz TMS的BOLD-fMRI反应与幅度和长度随训练长度的线性增加一致，可能提示1~2秒的刺激太长而不能代表脉冲。
Purpose: To measure motor and auditory cortex blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) response to impulse-like transcranial magnetic stimulation (TMS) pulses as a function of train length.Materials and Methods: Interleaved with fMRI at 1.5 T, TMS pulses 0.3-msec long were applied at 1 Hz to the motor cortex area for thumb. Six subjects were studied in a TR = 1 second session administering trains of 1, 2, 4, 8, and 16 pulses, and a TR = 3 seconds session administering trains of 1, 2, 4, 8, 16, and 24 pulses. A simple hemodynamic model with finite recovery and saturation was used to quantitatively characterize the BOLD-fMRI response as a function of train length.Results: In both the activations directly induced in motor cortex by TMS and the indirect activation sin auditory cortex caused by the sound of the TMS coil firing, the BOLD-fMRI responses to multiple pulses were well described by a summation of single-pulse impulse functions.Conclusion: Up to 24 discrete pulses, BOLD-fMRI response to 1 Hz TMS in both motor cortex and auditory cortex were consistent with a linear increase in amplitude and length with train length, possibly suggesting that stimuli of 1 to 2 seconds may be too long to represent impulses.