Role of Posterior Medial Thalamus in the Modulation of Striatal Circuitry and Choice Behavior.
Role of Posterior Medial Thalamus in the Modulation of Striatal Circuitry and Choice Behavior.
复制标题
后内侧丘脑在纹状体回路和选择行为调节中的作用。
DOI：
10.1101/2024.03.21.586152
复制
发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Margolis,DavidJ
中科院分区：
文献类型：
--
作者：
Yonk,AlexJ;Linares-García,Ivan;Pasternak,Logan;Juliani,SofiaE;Gradwell,MarkA;George,ArleneJ;Margolis,DavidJ
后内侧（POm）丘脑与感觉和运动回路密切相关，并且可能参与行为调节和感觉运动整合。 POm 向背侧纹状体提供轴突投射，背侧纹状体是感觉运动处理的热点，但 POm 纹状体投射的作用仍未确定。利用光遗传学和小鼠脑切片电生理学，我们发现 POm 为直接和间接通路纹状体棘投射神经元（分别为 D1-和 D2-SPN）和表达小清蛋白的快速尖峰中间神经元（PV）提供强大的突触输入。在头部受限的小鼠中执行基于胡须的触觉辨别任务期间，POm-纹状体投射显示出与预期相关的学习相关激活，但与奖励相关的瞳孔扩张无关。 POm-纹状体轴突在学习过程中的抑制导致反应时间变慢，并增加了专家表现的培训课程数量。我们的数据表明，POm-纹状体输入提供了行为相关的唤醒相关信号，这可能为后续选择相关输入的有效整合启动纹状体电路。
The posterior medial (POm) thalamus is heavily interconnected with sensory and motor circuitry and is likely involved in behavioral modulation and sensorimotor integration. POm provides axonal projections to the dorsal striatum, a hotspot of sensorimotor processing, yet the role of POm-striatal projections has remained undetermined. Using optogenetics with mouse brain slice electrophysiology, we found that POm provides robust synaptic input to direct and indirect pathway striatal spiny projection neurons (D1-and D2-SPNs, respectively) and parvalbumin-expressing fast spiking interneurons (PVs). During the performance of a whisker-based tactile discrimination task in head-restrained mice, POm-striatal projections displayed learning-related activation correlating with anticipatory, but not reward-related, pupil dilation. Inhibition of POm-striatal axons across learning caused slower reaction times and an increase in the number of training sessions for expert performance. Our data indicate that POm-striatal inputs provide a behaviorally relevant arousal-related signal, which may prime striatal circuitry for efficient integration of subsequent choice-related inputs.